RNA silencing: A remarkable parallel to protein-based immune systems in vertebrates?

被引：6

作者：

Chen, WZ ^{[1
]}

Liu, MQ ^{[1
]}

Cheng, G ^{[1
]}

Yan, WY ^{[1
]}

Fei, L ^{[1
]}

Zheng, ZX ^{[1
]}

机构：

[1] Fudan Univ, Inst Genet, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

来源：

FEBS LETTERS | 2005年 / 579卷 / 11期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

RNA silencing; RNA interference; interferon; protein-based immune system; vertebrates; evolution;

D O I：

10.1016/j.febslet.2005.03.055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sequence-specific gene silencing by double-strand RNA has been observed in many eukaryotes. Accumulating data suggest that it is the major antiviral defense mechanism in plants and invertebrates. The discovery that this cellular mechanism is also highly conserved though somewhat impaired in mammals has stimulated debate about the evolution of antiviral systems. Here we suggest that the existence of the interferon response as an evolutionary intermediate could account for both the relative decline of RNA silencing and the development of protein-based immune systems in vertebrates. In addition, we emphasize the opportunities presented by RNA silencing and the deeper understanding of vertebrate antiviral systems that is needed. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2267 / 2272

页数：6

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