The Iridium-Catalyzed Synthesis of Symmetrically and Unsymmetrically Alkylated Diamines under Mild Reaction Conditions

被引：107

作者：

Michlik, Stefan ^{[1
]}

Hille, Toni ^{[1
]}

Kempe, Rhett ^{[1
]}

机构：

[1] Lehrstuhl Anorgan Chem 2, D-95440 Bayreuth, Germany

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2012年 / 354卷 / 05期

关键词：

alcohols; alkylation; amine alkylation; amines; C?N bond formation; Dapson; diamines; iridium; P; N ligands; unsymmetrical alkylation; ASTERISK-IR COMPLEX; BORROWING HYDROGEN METHODOLOGY; UNCOMPLICATED FALCIPARUM-MALARIA; N-ALKYLATION; SECONDARY ALCOHOLS; TERTIARY-AMINES; BETA-ALKYLATION; SELECTIVE SYNTHESIS; ORGANIC-SYNTHESIS; ALIPHATIC-AMINES;

D O I：

10.1002/adsc.201100554

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An iridium catalyst stabilized by an anionic P,N ligand was used for the symmetrical and unsymmetrical monoalkylation of para-, meta-, and ortho-benzenediamines. Benzyl and aliphatic alcohols were used as alkylating reagents. 28 derivatives were synthesized. 14 of them are new compounds. Furthermore, the alkylation of the pharmacological important diamine Dapson (R) (dapsone) is described. 14 dapsone derivatives were synthesized among them 9 new compounds.

引用

页码：847 / 862

页数：16

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