Formin' adherens junctions

被引：15

作者：

Zigmond, S ^{[1
]}

机构：

[1] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 01期

关键词：

D O I：

10.1038/ncb0104-12

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epithelial cells are joined by adherens junctions, which consist of homotypic interactions between extracellular domains of E-cadherins. Inside the cell, the tails of E-cadherins bind actin cables through betacatenin and alpha-catenin. Formin1 is critically important for the formation of actin cables; it binds directly to alpha-catenin and can even bypass the need for alpha-catenin when targeted to beta-catenin.

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收藏

页码：12 / 14

页数：3

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