Sticky business: Orchestrating cellular signals at adherens junctions

被引：602

作者：

Perez-Moreno, M ^{[1
]}

Jamora, C ^{[1
]}

Fuchs, E ^{[1
]}

机构：

[1] Rockefeller Univ, Howard Hughes Med Inst, Lab Mammalian Cell Biol & Dev, New York, NY 10021 USA

来源：

CELL | 2003年 / 112卷 / 04期

关键词：

D O I：

10.1016/S0092-8674(03)00108-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cohesive sheets of epithelial cells are a fundamental feature of multicellular organisms and are largely a product of the varied functions of adherens junctions. These junctions and their cytoskeletal associations contribute heavily to the distinct shapes, polarity, spatially oriented mitotic spindle planes, and cellular movements of developing tissues. Deciphering the underlying mechanisms that govern these conserved cellular rearrangements is a prerequisite to understanding vertebrate morphogenesis.

引用

页码：535 / 548

页数：14

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