Concise synthesis of dihydrochalcones via palladium-catalyzed coupling of aryl halides and 1-aryl-2-propen-1-ols

被引：54

作者：

Briot, A

Baehr, C

Brouillard, R

Wagner, A

Mioskowski, C

机构：

[1] Univ Strasbourg 1, UMR 7514 CNRS, Fac Pharm, Lab Synth Bioorgan, F-67400 Illkirch Graffenstaden, France

[2] Univ Strasbourg 1, UMR 7509 CNRS, Lab Chim Polyphenols, F-67400 Illkirch Graffenstaden, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 04期

关键词：

D O I：

10.1021/jo034936c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An expedient route to substituted dihydrochalcones is reported. The key step is a palladium-assisted arylation of 1-aryl-2-propen-1-ols. This two-step/one-purification process allows the synthesis of a wide range of compounds with original substitution patterns, including polyphenolic derivatives.

引用

页码：1374 / 1377

页数：4

共 24 条

[1]

[Anonymous], 1999, The handbook of natural flavonoids

[2]

[Anonymous], FLAVONOIDS OTHER POL

[3]

BAKAL A, 1991, ALTERNATIVE SWEETNER

[4] The heck reaction as a sharpening stone of palladium catalysis [J].