Bis-5-alkylresorcinols from Panopsis rubescens that inhibit DNA polymerase β

被引:35
作者
Deng, JZ
Starck, SR
Hecht, SM [1 ]
机构
[1] Univ Virginia, Dept Chem, Charlottesville, VA 22901 USA
[2] Univ Virginia, Dept Biol, Charlottesville, VA 22901 USA
来源
JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 03期
关键词
D O I
10.1021/np980522g
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Bioassay-guided fractionation of Panopsis rubescens, using an assay to detect DNA polymerase beta inhibition, led to the isolation of two new bis-5-alkylresorcinols (1 and 2), in addition to one known bis-5-alkylresorcinol (3). The structures of 1-3 were established as 1,3-dihydroxy-5-[14'-(3",5"-dihydroxyphenyl)-cis-4'-[14'-(3",5"-dihydroxyp tetradecenyl]benzene (1), 1,3-dihydroxy-5-[14'-(3",5"-dihydroxyp (2), and 1,3-dihydroxy-5-[ 14'-(3",5"- dihydroxyphenyl)tetradecenyl]benzene (3), respectively, by spectroscopic and chemical analyses. Compounds 1-3 exhibited potent inhibition of calf thymus DNA polymerase beta, with IC50 values of 7.5, 6.5, and 5.8 mu M, respectively.
引用
收藏
页码:477 / 480
页数:4
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