Structural and functional aspects of prebiotics used in infant nutrition

被引:148
作者
Boehm, Guenther [1 ,2 ]
Moro, Guido [3 ]
机构
[1] Numico Res, D-61381 Friedrichsdorf, Germany
[2] Erasmus Univ, Sophia Childrens Hosp, NL-3015 GJ Rotterdam, Netherlands
[3] Matern Hosp Macedonio, Ctr Infant Nutr, I-20129 Milan, Italy
关键词
D O I
10.1093/jn/138.9.1818S
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Breast-feeding is associated with several benefits. Among them, the balanced postnatal development of the immune system is 1 of the key functions of breast-feeding. Although this effect is of multifactorial origin, it is widely accepted that the entire intestinal microbiota of breast-fed infants represents an important stimulating factor of the postnatal development of the immune system. The effect of breast-feeding on the intestinal microbiota can riot be attributed to a single compound, but there is accumulating evidence that human milk oligosaccharides play a crucial role. Because there is a broad consensus that the intestinal microbiota plays an important physiological role for the host, many attempts have been made to influence the intestinal flora by dietary interventions. This article summarizes results of intervention studies in which nonmilk oligosaccharides have been used to mimic the prebiotic effect of breast-feeding. A second focus has been related to the question of whether the prebiotic activity has beneficial effects on the postnatal development of the immune system. The data clearly demonstrate that prebiotics of nonmilk origin can mimic the prebiotic effect of breast-feeding, and this has positive consequences for the postnatal development of the immune system.
引用
收藏
页码:1818S / 1828S
页数:11
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