Interactions of the Human Pathogenic Brucella Species with Their Hosts

被引：216

作者：

Atluri, Vidya L. ^{[1
]}

Xavier, Mariana N. ^{[1
]}

de Jong, Maarten F. ^{[1
]}

den Hartigh, Andreas B. ^{[1
,2
]}

Tsolis, Renee M. ^{[1
]}

机构：

[1] Univ Calif Davis, Sch Med, Davis, CA 95616 USA

[2] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA

来源：

ANNUAL REVIEW OF MICROBIOLOGY, VOL 65 | 2011年 / 65卷

关键词：

brucellosis; zoonosis; granuloma; innate immunity; IV SECRETION SYSTEM; DENDRITIC CELL MATURATION; LIPID RAFT MICRODOMAINS; INNATE IMMUNE-RESPONSES; ABORTUS ROUGH MUTANTS; NATURAL-KILLER-CELLS; INTRACELLULAR SURVIVAL; ENDOPLASMIC-RETICULUM; MURINE MACROPHAGES; GENOME SEQUENCE;

D O I：

10.1146/annurev-micro-090110-102905

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Brucellosis is a zoonotic infection caused primarily by the bacterial pathogens Brucella melitensis and B. abortus. It is acquired by consumption of unpasteurized dairy products or by contact with infected animals. Globally, it is one of the most widespread zoonoses, with 500,000 new cases reported each year. In endemic areas, Brucella infections represent a serious public health problem that results in significant morbidity and economic losses. An important feature of the disease is persistent bacterial colonization of the reticuloendothelial system. In this review we discuss recent insights into mechanisms of intracellular survival and immune evasion that contribute to systemic persistence by the pathogenic Brucella species.

引用

页码：523 / 541

页数：19

共 124 条

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