Mouse models for telomere and telomerase biology

被引：19

作者：

Cheong, C ^{[1
]}

Hong, KU ^{[1
]}

Lee, HW ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Dept Mol Cell Biol, Samsung Biomed Res Inst, Suwon 440746, South Korea

来源：

EXPERIMENTAL AND MOLECULAR MEDICINE | 2003年 / 35卷 / 03期

关键词：

mouse model; telomerase; telomere; transgenic mouse;

D O I：

10.1038/emm.2003.20

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomeres serve a critical role in maintenance of genomic stability in all eukaryotes, from yeast to human. The maintenance of telomeres is achieved by the telomerase complex, which is largely composed of telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC). A variety of mouse models have provided valuable insights into the relationship between the telomerase complex and telomere dysfunction at the organismal level and helped understand their biological significance in human. Recently, in addition to its role in maintenance of the telomeres, novel functions of the telomerase complex have been emerging. In this review, studies of all gene-targeted or transgenic mouse models so far generated for telomerase and telomere biology are comprehensively described, and potential novel functions of telomerase are briefly discussed.

引用

收藏

页码：141 / 153

页数：13

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