Exercise intolerance in mitochondrial myopathy is not related to lactic acidosis

被引：30

作者：

Vissing, J

Gansted, U

Quistorff, B

机构：

[1] Rigshosp, Natl Univ Hosp, Dept Neurol 2082, DK-2100 Copenhagen, Denmark

[2] Rigshosp, Natl Univ Hosp, Copenhagen Muscle Res Ctr, DK-2100 Copenhagen, Denmark

[3] Univ Copenhagen, Panum Inst, NMR Ctr, DK-1168 Copenhagen, Denmark

来源：

ANNALS OF NEUROLOGY | 2001年 / 49卷 / 05期

关键词：

D O I：

10.1002/ana.1026

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In a double-blinded, placebo-controlled, crossover study in seven mitochondrial myopathy patients (MM), we investigated whether lowering of lactate with dichloroacetate (DCA) can improve exercise tolerance and oxidative capacity in MM. DCA lowered plasma lactate at rest and during exercise (from 10.5 +/- 2.0 to 5.0 +/- 1.6 mM; p = 0.005) but did not improve maximal work load or VO2 in cycle exercise or phosphorous magnetic resonance spectroscopy (P-31-MRS)-assessed indices of muscle oxidative metabolism. This indicates that lactate acidosis is not the primary cause of exercise intolerance in MM.

引用

收藏

页码：672 / 676

页数：5

相关论文

共 21 条

[11] Effects of dichloroacetate in three patients with MELAS [J].

Saitoh, S ;

Momoi, MY ;

Yamagata, T ;

Mori, Y ;

Imai, M .

NEUROLOGY, 1998, 50 (02) :531-534

[12] Effects of lactate on force production by mouse EDL muscle: implications for the development of fatigue [J].

Spangenburg, EE ;

Ward, CW ;

Williams, JH .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1998, 76 (06) :642-648

[13] THE PHARMACOLOGY OF DICHLOROACETATE [J].

STACPOOLE, PW .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1989, 38 (11) :1124-1144

[14] Combined aerobic training and dichloroacetate improve exercise capacity and indices of aerobic metabolism in muscle cytochrome oxidase deficiency [J].

Taivassalo, T ;

Matthews, PM ;

DeStefano, N ;

Sripathi, N ;

Genge, A ;

Karpati, G ;

Arnold, DL .

NEUROLOGY, 1996, 47 (02) :529-534

[15]

Tesch P, 1980, Acta Physiol Scand Suppl, V480, P1

[16] Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia [J].

Timmons, JA ;

Poucher, SM ;

ConstantinTeodosiu, D ;

Worrall, V ;

Macdonald, IA ;

Greenhaff, PL .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (03) :879-883

[17] Actively phosphorylating mitochondria are more resistant to lactic acidosis than inactive mitochondria [J].

Tonkonogi, M ;

Sahlin, K .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1999, 277 (02) :C288-C293

[18]

TRIVEDI B, 1966, J BIOL CHEM, V241, P4110

[19] Sympathetic activation in exercise is not dependent on muscle acidosis - Direct evidence from studies in metabolic myopathies [J].

Vissing, J ;

Vissing, SF ;

MacLean, DA ;

Saltin, B ;

Quistorff, B ;

Haller, RG .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (08) :1654-1660

[20] Exercise fuel mobilization in mitochondrial myopathy: A metabolic dilemma [J].

Vissing, J ;

Galbo, H ;

Haller, RG .

ANNALS OF NEUROLOGY, 1996, 40 (04) :655-662