Stereoselective synthesis of thiaerythrinanes based on an α-amidoalkylation/RCM approach

被引：16

作者：

Abdullah, Media Noori ^{[1
]}

Arrasate, Sonia ^{[1
]}

Lete, Esther ^{[1
]}

Sotomayor, Nuria ^{[1
]}

机构：

[1] Univ Basque Country, Euskal Herriko Unibertsitatea, Fac Ciencia & Tecnol, Dept Quim Organ 2, Bilbao 48080, Spain

来源：

TETRAHEDRON | 2008年 / 64卷 / 07期

关键词：

lithiation; lithium-halogen exchange; alpha-amidoalkylation; parham cyclisation; heterocycles; thiareythrinanes;

D O I：

10.1016/j.tet.2007.11.053

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Parham cyclisation-intermolecular alpha-amidoalkylation and nucleophilic addition-intramolecular alpha-amidoalkylation sequences constitute diastereocomplementary routes to 1,10b-cis and trans thiazolo[4,3-a]isoquinolinones. These thiazolidinediones, that incorporate allyl groups at C-1 and C-10b, are efficient precursors of thiacrythrinanes by ring-closing metathesis reactions. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1323 / 1332

页数：10

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