Solubility of paroxetine hydrochloride hemi-hydrate in (water plus acetone)

被引：28

作者：

Ren, GB ^{[1
]}

Wang, JK ^{[1
]}

Li, GZ ^{[1
]}

机构：

[1] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China

来源：

JOURNAL OF CHEMICAL THERMODYNAMICS | 2005年 / 37卷 / 08期

关键词：

solubility of paroxetine hydrochloride hemi-hydrate; combined nearly ideal binary solvent/Redlich-Kister equation; laser monitoring observation technique;

D O I：

10.1016/j.jct.2004.12.006

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Using a laser monitoring observation technique, the solubilities of paroxetine hydrochloride hemi-hydrate in (water + acetone) were determined by the synthetic method from (294.45 to 323.20) K, respectively. Results of these measurements were correlated by the three variants of the combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K) model. For the seven group data studied, three variants of the (CNIBS/R-K) equation were found to provide accurate mathematical representations of the experimental data and variant 2 is the best of the three variants. (c) 2004 Elsevier Ltd. All rights reserved.

引用

页码：860 / 865

页数：6

共 20 条

[1] MATHEMATICAL REPRESENTATION OF THERMODYNAMIC PROPERTIES .2. DERIVATION OF THE COMBINED NEARLY IDEAL BINARY SOLVENT (NIBS) REDLICH-KISTER MATHEMATICAL REPRESENTATION FROM A 2-BODY AND 3-BODY INTERACTIONAL MIXING MODEL [J].

ACREE, WE .

THERMOCHIMICA ACTA, 1992, 198 (01) :71-79

[2] THERMODYNAMIC PROPERTIES OF NONELECTROLYTE SOLUTIONS .4. ESTIMATION AND MATHEMATICAL REPRESENTATION OF SOLUTE ACTIVITY-COEFFICIENTS AND SOLUBILITIES IN BINARY SOLVENTS USING THE NIBS AND MODIFIED WILSON EQUATIONS [J].

ACREE, WE ;

ZVAIGZNE, AI .

THERMOCHIMICA ACTA, 1991, 178 :151-167

[3] Model for solubility estimation in mixed solvent systems - Comments [J].

Acree, WE .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 127 (01) :27-30

[4] A general model from theoretical cosolvency models [J].

BarzegarJalali, M ;

JouybanGharamaleki, A .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 152 (02) :247-250

[5] MODEL FOR SOLUBILITY ESTIMATION IN MIXED-SOLVENT SYSTEMS [J].

BARZEGARJALALI, M ;

HANAEE, J .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1994, 109 (03) :291-295

[6] Models for calculating solubility in binary solvent systems [J].

BarzegarJalali, M ;

JouybanGharamaleki, A .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 140 (02) :237-246

[7] Solubility of sodium dimethyl isophthalate-5-sulfonate in water and in water plus methanol containing sodium sulfate [J].

Jiang, Q ;

Gao, GH ;

Yu, YX ;

Qin, Y .

JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2000, 45 (02) :292-294

[8]

LACSSIE E, 2000, J CHROMATOGR B, V742, P229

[9] Method development and validation for the HPLC assay (potency and related substances) for 20 mg paroxetine tablets [J].

Lambropoulos, J ;

Spanos, GA ;

Lazaridis, NV .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1999, 19 (05) :793-802

[10] EXTENDED HILDEBRAND SOLUBILITY APPROACH AND THE LOG LINEAR SOLUBILITY EQUATION [J].

MARTIN, A ;

WU, PL ;

ADJEI, A ;

LINDSTROM, RE ;

ELWORTHY, PH .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1982, 71 (08) :849-856

← 1 2 →