Apolipoprotein E genotype and schizophrenia

被引：24

作者：

Chen, JY

Hong, CJ

Chiu, HJ

Lin, CY

Bai, YM

Song, HL

Lai, HC

Tsai, SJ

机构：

[1] Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan

[2] Yu Li Vet Hosp, Sect Psychiat, Taipei, Taiwan

[3] Natl Yang Ming Univ, Sch Med, Div Psychiat, Taipei 112, Taiwan

来源：

NEUROPSYCHOBIOLOGY | 1999年 / 39卷 / 03期

关键词：

apolipoprotein E; association study; genotype; schizophrenia;

D O I：

10.1159/000026573

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Schizophrenic disorders are complex genetic disorders and may involve multiple genes of small effect, The presence of apolipoprotein E (apoE) is associated with several neuropsychiatric disorders. Previous studies on apoE genotype distribution in schizophrenia have reported conflicting findings. We studied the genotype frequencies in a large group of schizophrenic patients. The genotype distribution was significantly different between the schizophrenic patients and the control subjects. Persons who were epsilon 3 carriers have an increased risk of schizophrenia. This result suggests that apoE isoforms may play a functional role in the pathogenesis of schizophrenic disorders, Some possible mechanisms regarding the effect of apoE on the development of schizophrenia are discussed.

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收藏

页码：141 / 143

页数：3

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