Cytotoxic cucurbitacin constituents from Sloanea zuliaensis

被引：26

作者：

Rodriguez, N

Vasquez, Y

Hussein, AA

Coley, PD

Solis, PN

Gupta, MP

机构：

[1] Univ Panama, Ctr Invest Farmacognost Flora Panamena, Fac Farm, Estafeta Univ, Panama City, Panama

[2] Smithsonian Trop Res Inst, Panama City, Panama

[3] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 11期

关键词：

D O I：

10.1021/np0303106

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new cucurbitacin D analogue, 2-deoxycucurbitacin D (1), as well as cucurbitacin D (2) and 25-acetylcucurbitacin F (3) were isolated from Sloanea zuliaensis. Compound 1 was found only in the young leaves of the plant and not in the mature leaves, and its structure was established using spectroscopic means. Compounds 1-3 demonstrated potent cytotoxic activity against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines.

引用

页码：1515 / 1516

页数：2

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