Cancers take their Toll - the function and regulation of Toll-like receptors in cancer cells

被引：172

作者：

Chen, R. ^{[2
]}

Alvero, A. B. ^{[1
]}

Silasi, D-A ^{[1
]}

Steffensen, K. D. ^{[3
]}

Mor, G. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, Reprod Immunol Unit, New Haven, CT 06520 USA

[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT USA

[3] Vejle Hosp, Dept Oncol, Vejle, Denmark

来源：

ONCOGENE | 2008年 / 27卷 / 02期

关键词：

ovarian cancer; Toll-like receptors; MyD88; inflammation; tissue repair; chemoresistance;

D O I：

10.1038/sj.onc.1210907

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore, it would not be surprising that factors that function in the tissue repair process, such as cytokines, chemokines, growth factors and Toll-like receptor (TLR) ligands, as well as growth signals for compensatory proliferation, would also be key factors in regulating and enhancing cancer progression. The TLR pathways, which play a critical role in tissue repair, are also key regulators in cancer progression as well as chemoresistance. TLRs serve as cell surface sensors that can initiate pathways leading to proliferation and chemoresistance; as well as mediators that are able to regulate the infiltrating immune cells to provide further support for cancer progression.

引用

页码：225 / 233

页数：9

共 76 条

[11] Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
Chen, Chun-Jen
Kono, Hajime
Golenbock, Douglas
Reed, George
Akira, Shizuo
Rock, Kenneth L.
[J]. NATURE MEDICINE, 2007, 13 (07) : 851 - 856
[12] CHEN R, 2007, UNPUB J CLIN INVEST
[13] Inflammation, cancer and chemoresistance: Taking advantage of the toll-like receptor signaling pathway
Chen, Rui
Alvero, Ayesha B.
Silasi, Dan-Arin
Mor, Gil
[J]. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2007, 57 (02) : 93 - 107
[14] Inflammation and cancer
Coussens, LM
Werb, Z
[J]. NATURE, 2002, 420 (6917) : 860 - 867
[15] Achieving stability of lipopolysaccharide-induced NF-κB activation
Covert, MW
Leung, TH
Gaston, JE
Baltimore, D
[J]. SCIENCE, 2005, 309 (5742) : 1854 - 1857
[16] Accumulation of miR-155 and BIC RNA in human B cell lymphomas
Eis, PS
Tam, W
Sun, LP
Chadburn, A
Li, ZD
Gomez, MF
Lund, E
Dahlberg, JE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (10) : 3627 - 3632
[17] Helicobacter pylori infection as a model for gastrointestinal immunity and chronic inflammatory diseases
Ernst, PB
Takaishi, H
Crowe, SE
[J]. DIGESTIVE DISEASES, 2001, 19 (02) : 104 - 111
[18] Oncomirs - microRNAs with a role in cancer
Esquela-Kerscher, A
Slack, FJ
[J]. NATURE REVIEWS CANCER, 2006, 6 (04) : 259 - 269
[19] Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis
Fukata, M
Michelsen, KS
Eri, R
Thomas, LS
Hu, B
Lukasek, K
Nast, CC
Lechago, J
Xu, RL
Naiki, Y
Soliman, A
Arditi, M
Abreu, MT
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2005, 288 (05): : G1055 - G1065
[20] Increase in immune cell infiltration with progression of oral epithelium from hyperkeratosis to dysplasia and carcinoma
Gannot, G
Gannot, I
Vered, H
Buchner, A
Keisari, Y
[J]. BRITISH JOURNAL OF CANCER, 2002, 86 (09) : 1444 - 1448

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