Detection of counterfeit Viagra® with Raman spectroscopy

被引：89

作者：

de Veij, Marleen ^{[1
]}

Deneckere, Annelien ^{[1
]}

Vandenabeele, Peter ^{[1
]}

de Kaste, Dries ^{[2
]}

Moens, Luc ^{[1
]}

机构：

[1] Univ Ghent, Analyt Chem Lab, B-9000 Ghent, Belgium

[2] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2008年 / 46卷 / 02期

关键词：

viagra (R); counterfeit drug detection; Raman spectroscopy; principal components analysis (PCA);

D O I：

10.1016/j.jpba.2007.10.021

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学]; 081704 [应用化学];

摘要：

During the last few years, counterfeiters have become increasingly sophisticated by falsifying drugs and making them look identical to genuine tablets. In this paper, Raman spectroscopy is proposed as a fast and reliable method for the detection of counterfeit Viagra(R) tablets. This technique can easily differentiate genuine from counterfeit tablets without the need of sample preparation. In total 18 tablets were analysed which all contained the active ingredient sildenafil, but different excipients were used, as could be observed in the Raman spectra between 1150 and 700 cm(-1). So, the spectra could be divided into genuine or counterfeit. Additionally, principal component analysis (PCA), combined with hierarchical cluster analysis (HCA), was used to establish an automated approach for the discrimination of counterfeit from genuine Viagra(R) tablets. Raman spectroscopy, combined with principal components analysis, could be used in the future by customs or in the field to identify counterfeit tablets on the spot without involvement of trained chemists. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：303 / 309

页数：7

共 33 条

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