Restricted isotypic antibody reactivity to hepatitis C virus synthetic peptides in immunocompromised patients

被引：3

作者：

Devesa, M

de Saez, A

León, G

Sirit, F

Cosson, C

Bermúdez, H

Liprandi, F

Noya, O

Pujol, FH

机构：

[1] Inst Venezolano Invest Cient, Ctr Microbiol & Biol Celular, Lab Biol Virus, Caracas 1020A, Venezuela

[2] Inst Venezolano Invest Cient, Quimbiotec, Planta Procesadora Derivados Sanguineos, Caracas, Venezuela

[3] Cent Univ Venezuela, Inst Trop Med, Secc Biohelmintiasis, Lab Sintesis Peptidos, Caracas, Venezuela

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 1999年 / 6卷 / 02期

关键词：

D O I：

10.1128/CDLI.6.2.279-281.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An enzyme immunoassay based on three synthetic peptides from the core, NS4, and NS5 regions of hepatitis C virus allowed the detection of antibodies in 100% of immunocompetent infected patients and in 91% of immunocompromised patients (hemodialysis and hemophiliac patients). Immune impairment seemed to restrict the spectrum of antibody isotypes reacting to the core peptide.

引用

收藏

页码：279 / 281

页数：3

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