PKB/AKT: Functional insights from genetic models

被引：526

作者：

Scheid, MP ^{[1
]}

Woodgett, JR ^{[1
]}

机构：

[1] Ontario Canc Inst, Toronto, ON M5G 2M9, Canada

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 10期

关键词：

D O I：

10.1038/35096067

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since its discovery 10 years ago, the potential functions of protein kinase B (PKB)/AKT have been catalogued with increasing efficiency. The physiological relevance of some of the proposed mechanisms by which PKB/AKT mediates many of its effects has been questioned, and recent work using new reagents and approaches has revealed some cracks in our understanding of this important molecule, and also hinted that these effects may involve other players.

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页码：760 / 768

页数：9

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