PKB/AKT: Functional insights from genetic models

被引：525

作者：

Scheid, MP ^{[1
]}

Woodgett, JR ^{[1
]}

机构：

[1] Ontario Canc Inst, Toronto, ON M5G 2M9, Canada

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 10期

关键词：

D O I：

10.1038/35096067

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since its discovery 10 years ago, the potential functions of protein kinase B (PKB)/AKT have been catalogued with increasing efficiency. The physiological relevance of some of the proposed mechanisms by which PKB/AKT mediates many of its effects has been questioned, and recent work using new reagents and approaches has revealed some cracks in our understanding of this important molecule, and also hinted that these effects may involve other players.

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收藏

页码：760 / 768

页数：9

相关论文

共 95 条

[41] Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2 [J].

Kobayashi, T ;

Cohen, P .

BIOCHEMICAL JOURNAL, 1999, 339 :319-328

[42] Direct control of the Forkhead transcription factor AFX by protein kinase B [J].

Kops, GJPL ;

de Ruiter, ND ;

De Vries-Smits, AMM ;

Powell, DR ;

Bos, JL ;

Burgering, BMT .

NATURE, 1999, 398 (6728) :630-634

[43] Lipid phosphatases in the immune system [J].

Krystal, G .

SEMINARS IN IMMUNOLOGY, 2000, 12 (04) :397-403

[44] The protooncogene TCL1 is an Akt kinase coactivator [J].

Laine, J ;

Künstle, G ;

Obata, T ;

Sha, M ;

Noguchi, M .

MOLECULAR CELL, 2000, 6 (02) :395-407

[45] Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome [J].

Liaw, D ;

Marsh, DJ ;

Li, J ;

Dahia, PLM ;

Wang, SI ;

Zheng, ZM ;

Bose, S ;

Call, KM ;

Tsou, HC ;

Peacocke, M ;

Eng, C ;

Parsons, R .

NATURE GENETICS, 1997, 16 (01) :64-67

[46] RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation [J].

Lim, CJ ;

Spiegelman, GB ;

Weeks, G .

EMBO JOURNAL, 2001, 20 (16) :4490-4499

[47] Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival [J].

Liu, D ;

Yang, XH ;

Zhou, SY .

CURRENT BIOLOGY, 2000, 10 (19) :1233-1236

[48]

Liu WG, 1997, CANCER RES, V57, P5254

[49] Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism [J].

Lynch, DK ;

Ellis, CA ;

Edwards, PAW ;

Hiles, ID .

ONCOGENE, 1999, 18 (56) :8024-8032

[50] The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate [J].

Maehama, T ;

Dixon, JE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (22) :13375-13378

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