Microbes, immunoregulation, and the gut

被引:240
作者
Rook, GAW [1 ]
Brunet, LR [1 ]
机构
[1] UCL Royal Free & Univ Coll Med Sch, Windeyer Inst Med Sci, Ctr Infect Dis & Int Hlth, London W1T 4JF, England
关键词
D O I
10.1136/gut.2004.053785
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Two distinct, but rapidly converging, areas of research ( the hygiene hypothesis and the study of probiotic/prebiotic effects) have emphasised the need to understand, and ultimately to manipulate, our physiological interactions with commensal flora, and with other transient but harmless organisms from the environment that affect immunoregulatory circuits. The story began with allergic disorders but now inflammatory bowel disease is increasingly involved.
引用
收藏
页码:317 / 320
页数:4
相关论文
共 40 条
[31]   Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: Antibiotics, probiotics, and prebiotics [J].
Sartor, RB .
GASTROENTEROLOGY, 2004, 126 (06) :1620-1633
[32]   Is the mucosal route of administration essential for probiotic function? Subcutaneous administration is associated with attenuation of murine colitis and arthritis [J].
Sheil, B ;
McCarthy, J ;
O'Mahony, L ;
Bennett, MW ;
Ryan, P ;
Fitzgibbon, JJ ;
Kiely, B ;
Collins, JK ;
Shanahan, F .
GUT, 2004, 53 (05) :694-700
[33]  
STANWELLSMITH R, 2004, HYGIENE HYPOTHESIS I
[34]   Relation between occurrence of type 1 diabetes and asthma [J].
Stene, LC ;
Nafstad, P .
LANCET, 2001, 357 (9256) :607-608
[35]  
TARKOWSKI A, 1990, J IMMUNOL, V144, P3770
[36]   A novel host-parasite lipid cross-talk - Schistosomal lyso-phosphatidylserine activates Toll-like receptor 2 and affects immune polarization [J].
van der Kleij, D ;
Latz, E ;
Brouwers, JFHM ;
Kruize, YCM ;
Schmitz, M ;
Kurt-Jones, EA ;
Espevik, T ;
de Jong, EC ;
Kapsenberg, ML ;
Golenbock, DT ;
Tielens, AGM ;
Yazdanbakhsh, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (50) :48122-48129
[37]   Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis [J].
Viglietta, V ;
Baecher-Allan, C ;
Weiner, HL ;
Hafler, DA .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (07) :971-979
[38]   Helminths and harmony [J].
Weinstock, JV ;
Summers, R ;
Elliott, DE .
GUT, 2004, 53 (01) :7-9
[39]   Parasites and the hygiene hypothesis - Regulating the immune system? [J].
Yazdanbakhsh, M ;
Matricardi, PM .
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2004, 26 (01) :15-23
[40]   Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells [J].
Zuany-Amorim, C ;
Sawicka, E ;
Manlius, C ;
Le Moine, AL ;
Brunet, LR ;
Kemeny, DM ;
Bowen, G ;
Rook, G ;
Walker, C .
NATURE MEDICINE, 2002, 8 (06) :625-629