Deletion of the 19kDa antigen does not alter the protective efficacy of BCG

被引：24

作者：

Yeremeev, VV

Stewart, GR

Neyrolles, O

Skrabal, K

Avdienko, VG

Apt, AS

Young, DB

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis & Microbiol, London W2 1PG, England

[2] Cent Inst TB, Immunogenet Lab, Moscow, Russia

来源：

TUBERCLE AND LUNG DISEASE | 2000年 / 80卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1054/tuld.2000.0252

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Expression of the Mycobacterium tuberculosis 19kDa lipoprotein in saprophytic mycobacteria has been found to reduce their ability to prime a protective response to subsequent virulent challenge in the mouse model. The present study was designed to test whether 19kDa expression has an analogous detrimental effect on the efficacy of BCG vaccination. In contrast to the results in saprophytes, neither overexpression of the 19kDa antigen, nor deletion of the endogenous 19kDa gene altered the ability of BCG to protect against M. tuberculosis challenge in a mouse model. (C) 2001 Harcourt Publishers Ltd.

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收藏

页码：243 / 247

页数：5

相关论文

共 9 条

[1] Induction of a type 1 immune response to a recombinant antigen from Mycobacterium tuberculosis expressed in Mycobacterium vaccae [J].

AbouZeid, C ;

Gares, MP ;

Inwald, J ;

Janssen, R ;

Zhang, Y ;

Young, DB ;

Hetzel, C ;

Lamb, JR ;

Baldwin, SL ;

Orme, IM ;

Yeremeev, V ;

Nikonenko, BV ;

Apt, AS .

INFECTION AND IMMUNITY, 1997, 65 (05) :1856-1862

[2] Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors [J].

Brightbill, HD ;

Libraty, DH ;

Krutzik, SR ;

Yang, RB ;

Belisle, JT ;

Bleharski, JR ;

Maitland, M ;

Norgard, MV ;

Plevy, SE ;

Smale, ST ;

Brennan, PJ ;

Bloom, BR ;

Godowski, PJ ;

Modlin, RL .

SCIENCE, 1999, 285 (5428) :732-736

[3] EXPRESSION OF THE MYCOBACTERIUM-TUBERCULOSIS 19-KILODALTON ANTIGEN IN MYCOBACTERIUM-SMEGMATIS - IMMUNOLOGICAL ANALYSIS AND EVIDENCE OF GLYCOSYLATION [J].

GARBE, T ;

HARRIS, D ;

VORDERMEIER, M ;

LATHIGRA, R ;

IVANYI, J ;

YOUNG, D .

INFECTION AND IMMUNITY, 1993, 61 (01) :260-267

[4] TRANSFORMATION OF MYCOBACTERIAL SPECIES USING HYGROMYCIN RESISTANCE AS SELECTABLE MARKER [J].

GARBE, TR ;

BARATHI, J ;

BARNINI, S ;

ZHANG, Y ;

ABOUZEID, C ;

TANG, D ;

MUKHERJEE, R ;

YOUNG, DB .

MICROBIOLOGY-SGM, 1994, 140 :133-138

[5] Lack of production of the 19-kDa glycolipoprotein in certain strains of Mycobacterium tuberculosis [J].

Lathigra, R ;

Zhang, Y ;

Hill, M ;

Garcia, MJ ;

Jackett, PS ;

Ivanyi, J .

RESEARCH IN MICROBIOLOGY, 1996, 147 (04) :237-249

[6]

MATHENTHIRALING.E, 1998, INFECT IMMUN, V66, P3626

[7] Expression of the Bacillus subtilis sacB gene confers sucrose sensitivity on mycobacteria [J].

Pelicic, V ;

Reyrat, JM ;

Gicquel, B .

JOURNAL OF BACTERIOLOGY, 1996, 178 (04) :1197-1199

[8] The 19-kD antigen and protective immunity in a murine model of tuberculosis [J].

Yeremeev, VV ;

Lyadova, IV ;

Nikonenko, BV ;

Apt, AS ;

Abou-Zeid, C ;

Inwald, J ;

Young, DB .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2000, 120 (02) :274-279

[9] Vaccination with recombinant vaccinia viruses protects mice against Mycobacterium tuberculosis infection [J].

Zhu, X ;

Venkataprasad, N ;

Ivanyi, J ;

Vordermeier, HM .

IMMUNOLOGY, 1997, 92 (01) :6-9