Satisfying turns in folding transitions

被引：34

作者：

Gruebele, M

Wolynes, PG

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

[2] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA

来源：

NATURE STRUCTURAL BIOLOGY | 1998年 / 5卷 / 08期

关键词：

D O I：

10.1038/1354

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein engineering studies show that conformations in the folding transition state ensemble can be structurally polarized. In two SH3 beta-sheet domains, the formation of hydrophobic contacts goes hand in hand with the formation of the solvated distal loop beta-turn, while large parts of the molecule remain unstructured in the ensemble.

引用

页码：662 / 665

页数：4

共 22 条

[1] Observation of distinct nanosecond and microsecond protein folding events [J].

Ballew, RM ;

Sabelko, J ;

Gruebele, M .

NATURE STRUCTURAL BIOLOGY, 1996, 3 (11) :923-926

[2] The energy landscape of a fast-folding protein mapped by Ala->Gly substitutions [J].

Burton, RE ;

Huang, GS ;

Daugherty, MA ;

Calderone, TL ;

Oas, TG .

NATURE STRUCTURAL BIOLOGY, 1997, 4 (04) :305-310

[3] Rate of protein folding near the point of thermodynamic equilibrium between the coil and the most stable chain fold [J].

Finkelstein, AV ;

Badretdinov, AY .

FOLDING & DESIGN, 1997, 2 (02) :115-121

[4]

Flory P. J., 1969, STAT MECH CHAIN MOL

[5] Important role of hydrogen bonds in the structurally polarized transition state for folding of the src SH3 domain [J].

Grantcharova, VP ;

Riddle, DS ;

Santiago, JV ;

Baker, D .

NATURE STRUCTURAL BIOLOGY, 1998, 5 (08) :714-720

[6] The nucleation-collapse mechanism in protein folding: evidence for the non-uniqueness of the folding nucleus [J].

Guo, ZY ;

Thirumalai, D .

FOLDING & DESIGN, 1997, 2 (06) :377-391

[7] THE NATURE OF FOLDED STATES OF GLOBULAR-PROTEINS [J].

HONEYCUTT, JD ;

THIRUMALAI, D .

BIOPOLYMERS, 1992, 32 (06) :695-709

[8]

ITHZAKI LS, 1995, J MOL BIOL, V254, P260

[9] FORMATION OF A MOLTEN GLOBULE INTERMEDIATE EARLY IN THE KINETIC FOLDING PATHWAY OF APOMYOGLOBIN [J].

JENNINGS, PA ;

WRIGHT, PE .

SCIENCE, 1993, 262 (5135) :892-896

[10] The sequences of small proteins are not extensively optimized for rapid folding by natural selection [J].

Kim, DE ;

Gu, HD ;

Baker, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) :4982-4986

← 1 2 3 →