Modular pyridine-type P,N-ligands derived from monoterpenes:: application in asymmetric Heck addition

被引：61

作者：

Malkov, AV ^{[1
]}

Bella, M ^{[1
]}

Stará, IG ^{[1
]}

Kocovsky, P ^{[1
]}

机构：

[1] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 16期

关键词：

D O I：

10.1016/S0040-4039(01)00369-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel (diphenylphosphinophenyl)pyridine ligands (+)-8, (+)-15, (-)-21, and (-)-26 were synthesized from (-)-beta -pinene, (+)-3-carene, (+)-2-carene, and (-)-alpha -pinene, respectively, via Krohnke annulation as the key step, and shown to effect less than or equal to 88% ee in Heck addition (27 --> 28). Ligands (+)-15 and (-)-21 are quasi-enantiomeric; ligands 8 and 26 can be prepared in both enantiomeric forms from (+)- and (-)-enantiomers of alpha- and beta -pinene, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3045 / 3048

页数：4

共 46 条

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