West Nile Virus RNA Not Detected in Urine of 40 People Tested 6 Years After Acute West Nile Virus Disease

被引：39

作者：

Gibney, Katherine B. ^{[1
,2
]}

Lanciotti, Robert S. ^{[1
]}

Sejvar, James J. ^{[1
]}

Nugent, C. Thomas ^{[3
]}

Linnen, Jeffrey M. ^{[3
]}

Delorey, Mark J. ^{[1
]}

Lehman, Jennifer A. ^{[1
]}

Boswell, Erin N. ^{[1
]}

Staples, J. Erin ^{[1
]}

Fischer, Marc ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO 80521 USA

[2] Ctr Dis Control & Prevent, Epidem Intelligence Serv Off, Atlanta, GA USA

[3] Gen Probe Inc, San Diego, CA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 203卷 / 03期

关键词：

INFECTION;

D O I：

10.1093/infdis/jiq057

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

West Nile virus (WNV) causes an acute infection that is usually cleared by an effective immune response after several days of viremia. However, a recent study detected WNV RNA in the urine of 5 of 25 persons (20%) tested several years after their initial acute WNV disease. We evaluated an established cohort of 40 persons >6 years after initial infection with WNV. Urine collected from all participants tested negative for WNV RNA by reverse-transcription polymerase chain reaction and transcription-mediated amplification. Prospective studies are needed to determine if and for how long WNV persists in urine following WNV disease.

引用

页码：344 / 347

页数：4

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