Interrelationships between μ opioid and melanocortin receptors in mediating food intake in rats

被引：36

作者：

Grossman, HC

Hadjimarkou, MM

Silva, RM

Giraudo, SQ

Bodnar, RJ ^{[1
]}

机构：

[1] CUNY Queens Coll, Dept Psychol & Neuropsychol Doctoral Sub Program, Flushing, NY 11367 USA

[2] Univ Georgia, Dept Food & Nutr, Athens, GA 30602 USA

来源：

BRAIN RESEARCH | 2003年 / 991卷 / 1-2期

关键词：

food intake; body weight; beta-endorphin; SHU-9119; MTII; beta-funaltrexamine;

D O I：

10.1016/S0006-8993(03)03442-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study examined the interrelationships between feeding responses produced by g opioid receptor agonists and melanocortin-3 or 4 (MC-3/4) receptor antagonists. Feeding induced by the g-sensitive opioid peptide, beta-endorphin (betaEND, 10 mug, icv) was significantly and dose-dependently reduced by pretreatment with the MC-3/4 receptor agonist, melanotan-II (MTII 0.01-10 nmol, icv). Moreover, the selective p opioid antagonist, beta-funaltrexamine (betaFNA: 2-20 mug, icv), significantly and dose-dependently reduced feeding and weight gain elicited by the potent MC-3/4 receptor antagonist, SHU-9119 (0.5 nmol, icv), especially at those intake periods (24-48 h) when SHU-9119 produced maximal ingestive effects. These data extend previous findings demonstrating interactions between opioid and melanocortin receptors in the mediation of food intake. (C) 2003 Elsevier B.V. All rights reserved.

引用

收藏

页码：240 / 244

页数：5

相关论文

共 44 条

[1] Role of leptin in the neuroendocrine response to fasting [J].

Ahima, RS ;

Prabakaran, D ;

Mantzoros, C ;

Qu, DQ ;

Lowell, B ;

MaratosFlier, E ;

Flier, JS .

NATURE, 1996, 382 (6588) :250-252

[2] REDUCTION BY CENTRAL BETA-FUNALTREXAMINE OF FOOD-INTAKE IN RATS UNDER FREELY-FEEDING, DEPRIVATION AND GLUCOPRIVIC CONDITIONS [J].

ARJUNE, D ;

STANDIFER, KM ;

PASTERNAK, GW ;

BODNAR, RJ .

BRAIN RESEARCH, 1990, 535 (01) :101-109

[3] Central injection in rats of α-melanocyte-stimulating hormone analog:: effects on food intake and brain Fos [J].

Brown, KS ;

Gentry, RM ;

Rowland, NE .

REGULATORY PEPTIDES, 1998, 78 (1-3) :89-94

[4] Combined blockade of both μ- and κ-opioid receptors prevents the acute orexigenic action of agouti-related protein [J].

Brugman, S ;

Clegg, DJ ;

Woods, SC ;

Seeley, RJ .

ENDOCRINOLOGY, 2002, 143 (11) :4265-4270

[5] RECOMBINANT MOUSE OB PROTEIN - EVIDENCE FOR A PERIPHERAL SIGNAL LINKING ADIPOSITY AND CENTRAL NEURAL NETWORKS [J].

CAMPFIELD, LA ;

SMITH, FJ ;

GUISEZ, Y ;

DEVOS, R ;

BURN, P .

SCIENCE, 1995, 269 (5223) :546-549

[6] Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat [J].

Cowley, MA ;

Pronchuk, N ;

Fan, W ;

Dinulescu, DM ;

Colmers, WF ;

Cone, RD .

NEURON, 1999, 24 (01) :155-163

[7] Mu-opioid receptor is involved in beta-endorphin-induced feeding in goldfish [J].

dePedro, N ;

Cespedes, MV ;

Delgado, MJ ;

AlonsoBedate, M .

PEPTIDES, 1996, 17 (03) :421-424

[8] CENTRAL ADMINISTRATION OF BETA-ENDORPHIN INCREASES FOOD-INTAKE IN GOLDFISH - PRETREATMENT WITH THE OPIOID ANTAGONIST NALOXONE [J].

DEPEDRO, N ;

DELGADO, MJ ;

ALONSOBEDATE, M .

REGULATORY PEPTIDES, 1995, 55 (02) :189-195

[9] Role of melanocortinergic neurons in feeding and the agouti obesity syndrome [J].

Fan, W ;

Boston, BA ;

Kesterson, RA ;

Hruby, VJ ;

Cone, RD .

NATURE, 1997, 385 (6612) :165-168

[10] Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands [J].

Giraudo, SQ ;

Billington, CJ ;

Levine, AS .

BRAIN RESEARCH, 1998, 809 (02) :302-306

← 1 2 3 4 5 →