The role of Dectin-1 in the host defence against fungal infections

被引：270

作者：

Drummond, Rebecca A. ^{[1
]}

Brown, Gordon D. ^{[1
]}

机构：

[1] Univ Aberdeen, Aberdeen Fungal Grp, Sect Immun & Infect, Inst Med Sci, Aberdeen AB25 2ZD, Scotland

来源：

CURRENT OPINION IN MICROBIOLOGY | 2011年 / 14卷 / 04期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

CANDIDA-ALBICANS YEAST; BETA-GLUCAN RECEPTOR; NLRP3; INFLAMMASOME; PNEUMOCYSTIS-CARINII; CYTOKINE PRODUCTION; INNATE IMMUNITY; RECOGNITION; ACTIVATION; SYK; EXPRESSION;

D O I：

10.1016/j.mib.2011.07.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Dectin-1 is an innate immune pattern recognition receptor (PRR) that, through its ability to bind beta-glucans, is involved in the recognition of several pathogenic fungi. Dectin-1 can stimulate a variety of cellular responses via the Syk/CARD9 signalling pathway, including phagocytosis, cytokine production and the respiratory burst. Several advances in our understanding of Dectin-1 immunobiology have been made in recent years, including characterisation of additional signalling pathways and demonstration of its ability to directly induce the development of adaptive immunity. However, the physiological role of many of the functions of this receptor is still unclear. This review aims to provide an update on Dectin-1 and its role within antifungal immune responses, focussing on progress made in the last two years.

引用

页码：392 / 399

页数：8

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