Brain membrane phospholipid alterations in Alzheimer's disease

被引:239
作者
Pettegrew, JW
Panchalingam, K
Hamilton, RL
McClure, RJ
机构
[1] Univ Pittsburgh, Lab Neurophys, Dept Psychiat, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15213 USA
[3] Univ Pittsburgh, Sch Med, Dept Pathol, Div Neuropathol, Pittsburgh, PA 15213 USA
[4] Univ Pittsburgh, Neurol & Hlth Serv Adm, Grad Sch Publ Hlth, Pittsburgh, PA 15213 USA
关键词
phospholipid metabolism; Alzheimer's disease; apolipoprotein E; P-31; NMR; phosphatidylethanolamine; phosphatidylethanolamine plasmalogen; phosphatidylinositol; sphingomyelin; diphosphatidylglycerol;
D O I
10.1023/A:1011603916962
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Studies have demonstrated alterations in brain membrane phospholipid metabolite levels in Alzheimer's disease (AD). The changes in phospholipid metabolite levels correlate with neuropathological hallmarks of the disease and measures of cognitive decline. This P-31 nuclear magnetic resonance (NMR) study of Folch extracts of autopsy material reveals significant reductions in AD brain levels of phosphatidylethanolamine (PtdEtn) and phosphatidylinositol (PtdIns), and elevations in sphingomyelin (SPH) and the plasmalogen derivative of PtdEtn. In the superior temporal gyrus, there were additional reductions in the levels of diphosphatidyl-glycerol (DPG) and phosphatidic acid (PtdA). The findings are present in 3/3 as well as 3/4 and 4/4 apolipoprotein E (apoE) genotypes. The AD findings do not appear to reflect non-specific neurodegeneration or the presence of gliosis. The present findings could possibly contribute to an abnormal membrane repair in AD brains which ultimately results in synaptic loss and the aggregation of A beta peptide.
引用
收藏
页码:771 / 782
页数:12
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