Human minisatellite mutation rate after the Chernobyl accident

被引：304

作者：

Dubrova, YE

Nesterov, VN

Krouchinsky, NG

Ostapenko, VA

Neumann, R

Neil, DL

Jeffreys, AJ

机构：

[1] UNIV LEICESTER, DEPT GENET, LEICESTER LE1 7RH, LEICS, ENGLAND

[2] RES INST RADIAT MED, MOGILYOV 212004, BELARUS

来源：

NATURE | 1996年 / 380卷 / 6576期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/380683a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Germline mutation at human minisatellite loci has been studied among children horn in heavily polluted areas of the Mogilev district of Belarus after the Chernobyl accident and in a control population. The frequency of mutation was found to be twice as high in the exposed families as in the control group. Mutation rate in the Mogilev families was correlated with the level of caesium-137 surface contamination, consistent with radiation induction of germline mutation.

引用

页码：683 / 686

页数：4

共 31 条

[1] THE GLOBAL IMPACT OF THE CHERNOBYL REACTOR ACCIDENT
ANSPAUGH, LR
CATLIN, RJ
GOLDMAN, M
[J]. SCIENCE, 1988, 242 (4885) : 1513 - 1519
[2] BOCHKOV NP, 1993, VESTN ROS AKAD MED+, P51
[3] INVERSE DOSE-RATE EFFECT FOR THE INDUCTION OF 6-THIOGUANINE-RESISTANT MUTANTS IN CHINESE-HAMSTER V79-S CELLS BY 60CO-GAMMA-RAYS
CROMPTON, NEA
BARTH, B
KIEFER, J
[J]. RADIATION RESEARCH, 1990, 124 (03) : 300 - 308
[4] DROSDOVITCH VV, 1989, PROGNOSIS DOSES EXPO
[5] MOUSE MINISATELLITE MUTATIONS INDUCED BY IONIZING-RADIATION
DUBROVA, YE
JEFFREYS, AJ
MALASHENKO, AM
[J]. NATURE GENETICS, 1993, 5 (01) : 92 - 94
[6] FAN YF, 1995, NT J RAD BIOL, V68, P177
[7] MUTATIONAL SPECTRUM OF X-RAY-INDUCED TK- HUMAN CELL MUTANTS
GIVER, CR
NELSON, SL
CHA, MY
PONGSAENSOOK, P
GROSOVSKY, AJ
[J]. CARCINOGENESIS, 1995, 16 (02) : 267 - 275
[8] COMPLEX GENE CONVERSION EVENTS IN GERMLINE MUTATION AT HUMAN MINISATELLITES
JEFFREYS, AJ
TAMAKI, K
MACLEOD, A
MONCKTON, DG
NEIL, DL
ARMOUR, JAL
[J]. NATURE GENETICS, 1994, 6 (02) : 136 - 145
[9] MINISATELLITE REPEAT CODING AS A DIGITAL APPROACH TO DNA TYPING
JEFFREYS, AJ
MACLEOD, A
TAMAKI, K
NEIL, DL
MONCKTON, DG
[J]. NATURE, 1991, 354 (6350) : 204 - 209
[10] SPONTANEOUS MUTATION-RATES TO NEW LENGTH ALLELES AT TANDEM-REPETITIVE HYPERVARIABLE LOCI IN HUMAN DNA
JEFFREYS, AJ
ROYLE, NJ
WILSON, V
WONG, Z
[J]. NATURE, 1988, 332 (6161) : 278 - 281

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