Angiotensin and its AT2 receptor:: new insights into an old system

被引：94

作者：

Stoll, M ^{[1
]}

Unger, T ^{[1
]}

机构：

[1] Univ Kiel, Inst Pharmacol, D-24105 Kiel, Germany

来源：

REGULATORY PEPTIDES | 2001年 / 99卷 / 2-3期

关键词：

angiotensin; AT(2) receptor; signal transduction growth; differentiation; apoptosis; regeneration;

D O I：

10.1016/S0167-0115(01)00246-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The AT(2) receptor represents a true receptor, but signals and functions in unexpected ways compared to the respective features of the 'classical' AT(1) receptor. Moreover, some of the actions of the AT(2) receptor are even directly opposed to those of the AT(1) receptor, especially concerning the growth- and differentiation-modulating actions of ANG II. The regulation of the AT(2) receptor itself by its agonist, as well as by growth factors during ontogenesis, and its acknowledged effects on the regulation of cell growth, differentiation and apoptosis, points towards a role of a program modulator in embryonic development and regeneration. (C) 2001 Elsevier Science B.V. All rights reserved.

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页码：175 / 182

页数：8

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