Impact of tumor Epstein-Barr virus status on presenting features and outcome in age-defined subgroups of patients with classic Hodgkin lymphoma: a population-based study

被引:156
作者
Jarrett, RF
Stark, GL
White, J
Angus, B
Alexander, FE
Krajewski, AS
Freeland, J
Taylor, GM
Taylor, PRA
机构
[1] Royal Victoria Infirm, Dept Haematol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England
[2] Univ Glasgow, Leukaemia Res Fund Virus Ctr, Inst Comparat Med, Glasgow, Lanark, Scotland
[3] Univ Edinburgh, Edinburgh, Midlothian, Scotland
[4] Northampton Gen Natl Hlth Serv NHS Trust, Northampton, England
[5] St Marys Hosp, Manchester M13 0JH, Lancs, England
关键词
D O I
10.1182/blood-2004-09-3759
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The association between tumor Epstein-Barr virus (EBV) status and clinical outcome in Hodgkin lymphoma (HL) is controversial. This population-based study assessed the impact of EBV status on survival in age-stratified cohorts of adults with classic HL (cHL). Data from 437 cases were analyzed with a median follow-up of 93 months. Overall survival (OS) was significantly better for EBV-negative compared with EBV-positive patients (P <.001), with 5-year survival rates of 81% and 66%, respectively; disease-specific survival (DSS) was also greater for EBV-negative patients (P =.03). The impact of EBV status varied with age at diagnosis. In patients aged 16 to 34 years, EBV-associated cases had a survival advantage compared with EBV-negative cases, but differences were not statistically significant (P =.21). Among patients 50 years or older, EBV positivity was associated with a significantly poorer outcome (P =.003). Excess deaths occurred in EBV-positive patients with both early- and advanced-stage disease. In multivariate analysis of OS in the older patients, EBV status retained statistical significance after adjusting for the effects of sex, stage, and B symptoms (P =.01). Impaired immune status may contribute to the development of EBV-positive cHL in older patients, and strategies aimed at boosting the immune response should be investigated in the treatment of these patients.
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页码:2444 / 2451
页数:8
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