Development and functions of the choroid plexus-cerebrospinal fluid system

被引：439

作者：

Lun, Melody P. ^{[1
,2
]}

Monuki, Edwin S. ^{[3
]}

Lehtinen, Maria K. ^{[1
]}

机构：

[1] Boston Childrens Hosp, Dept Pathol, Boston, MA 02115 USA

[2] Boston Univ, Sch Med, Dept Pathol & Lab Med, Boston, MA 02118 USA

[3] Univ Calif Irvine, Sch Med, Dept Pathol & Lab Med, Irvine, CA 92697 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2015年 / 16卷 / 08期

关键词：

NEURAL STEM-CELLS; ROOF PLATE; SONIC HEDGEHOG; LEUKOCYTE RECRUITMENT; DORSAL TELENCEPHALON; IMMUNE SURVEILLANCE; BRAIN ENLARGEMENT; OTX2; HOMEOPROTEIN; CEREBRAL-CORTEX; RHOMBIC LIP;

D O I：

10.1038/nrn3921

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The choroid plexus (ChP) is the principal source of cerebrospinal fluid (CSF), which has accepted roles as a fluid cushion and a sink for nervous system waste in vertebrates. Various animal models have provided insights into how the ChP-CSF system develops and matures. In addition, recent studies have uncovered new, active roles for this dynamic system in the regulation of neural stem cells, critical periods and the overall health of the nervous system. Together, these findings have brought about a paradigm shift in our understanding of brain development and health, and have stimulated new initiatives for the treatment of neurological disease.

引用

页码：445 / 457

页数：13

共 169 条

[1] KCNQ1, KCNE2, and Na+-Coupled Solute Transporters Form Reciprocally Regulating Complexes That Affect Neuronal Excitability [J].

Abbott, Geoffrey W. ;

Tai, Kwok-Keung ;

Neverisky, Daniel L. ;

Hansler, Alex ;

Hu, Zhaoyang ;

Roepke, Torsten K. ;

Lerner, Daniel J. ;

Chen, Qiuying ;

Liu, Li ;

Zupan, Bojana ;

Toth, Miklos ;

Haynes, Robin ;

Huang, Xiaoping ;

Demirbas, Didem ;

Buccafusca, Roberto ;

Gross, Steven S. ;

Kanda, Vikram A. ;

Berry, Gerard T. .

SCIENCE SIGNALING, 2014, 7 (315)

[2]

[Anonymous], NATURE

[3] Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis [J].

Arbeille, Elise ;

Reynaud, Florie ;

Sanyas, Isabelle ;

Bozon, Muriel ;

Kindbeiter, Karine ;

Causeret, Frederic ;

Pierani, Alessandra ;

Falk, Julien ;

Moret, Frederic ;

Castellani, Valerie .

NATURE COMMUNICATIONS, 2015, 6

[4] Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation [J].

Awatramani, R ;

Soriano, P ;

Rodriguez, C ;

Mai, JJ ;

Dymecki, SM .

NATURE GENETICS, 2003, 35 (01) :70-75

[5] Morphology of the roof plate of the forebrain and the lateral choroid plexuses in the human embryo [J].

Bailey, P .

JOURNAL OF COMPARATIVE NEUROLOGY, 1916, 26 (01) :79-120

[6] Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus [J].

Banizs, B ;

Pike, MM ;

Millican, CL ;

Ferguson, WB ;

Komlosi, P ;

Sheetz, J ;

Bell, PD ;

Schwiebert, EM ;

Yoder, BK .

DEVELOPMENT, 2005, 132 (23) :5329-5339

[7] Altered pHi regulation and Na+/HCO3- transporter activity in choroid plexus of cilia-defective Tg737orpk mutant mouse [J].

Banizs, Boglarka ;

Komlosi, Peter ;

Bevensee, Mark O. ;

Schwiebert, Erik M. ;

Bell, Phillip D. ;

Yoder, Bradley K. .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2007, 292 (04) :C1409-C1416

[8] Proliferation of Cultured Mouse Choroid Plexus Epithelial Cells [J].

Barkho, Basam Z. ;

Monuki, Edwin S. .

PLOS ONE, 2015, 10 (03)

[9] Aging-induced type I interferon response at the choroid plexus negatively affects brain function [J].

Baruch, Kuti ;

Deczkowska, Aleksandra ;

David, Eyal ;

Castellano, Joseph M. ;

Miller, Omer ;

Kertser, Alexander ;

Berkutzki, Tamara ;

Barnett-Itzhaki, Zohar ;

Bezalel, Dana ;

Wyss-Coray, Tony ;

Amit, Ido ;

Schwartz, Michal .

SCIENCE, 2014, 346 (6205) :89-93

[10] POSTNATAL-DEVELOPMENT OF BULK FLOW IN CEREBROSPINAL-FLUID SYSTEM OF ALBINO-RAT - CLEARANCE OF CARBOXYL-[C-14]INULIN AFTER INTRATHECAL INFUSION [J].

BASS, NH ;

LUNDBORG, P .

BRAIN RESEARCH, 1973, 52 (MAR30) :323-332

← 1 2 3 4 5 6 7 8 9 10 →