Development and functions of the choroid plexus-cerebrospinal fluid system

被引：439

作者：

Lun, Melody P. ^{[1
,2
]}

Monuki, Edwin S. ^{[3
]}

Lehtinen, Maria K. ^{[1
]}

机构：

[1] Boston Childrens Hosp, Dept Pathol, Boston, MA 02115 USA

[2] Boston Univ, Sch Med, Dept Pathol & Lab Med, Boston, MA 02118 USA

[3] Univ Calif Irvine, Sch Med, Dept Pathol & Lab Med, Irvine, CA 92697 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2015年 / 16卷 / 08期

关键词：

NEURAL STEM-CELLS; ROOF PLATE; SONIC HEDGEHOG; LEUKOCYTE RECRUITMENT; DORSAL TELENCEPHALON; IMMUNE SURVEILLANCE; BRAIN ENLARGEMENT; OTX2; HOMEOPROTEIN; CEREBRAL-CORTEX; RHOMBIC LIP;

D O I：

10.1038/nrn3921

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The choroid plexus (ChP) is the principal source of cerebrospinal fluid (CSF), which has accepted roles as a fluid cushion and a sink for nervous system waste in vertebrates. Various animal models have provided insights into how the ChP-CSF system develops and matures. In addition, recent studies have uncovered new, active roles for this dynamic system in the regulation of neural stem cells, critical periods and the overall health of the nervous system. Together, these findings have brought about a paradigm shift in our understanding of brain development and health, and have stimulated new initiatives for the treatment of neurological disease.

引用

页码：445 / 457

页数：13

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