Optical properties of the mouse eye

被引:110
作者
Geng, Ying [1 ,2 ]
Schery, Lee Anne [1 ]
Sharma, Robin [1 ,2 ]
Dubra, Alfredo [1 ,3 ]
Ahmad, Kamran [1 ]
Libby, Richard T. [1 ,3 ]
Williams, David R. [1 ,2 ,3 ]
机构
[1] Univ Rochester, Ctr Visual Sci, Rochester, NY 14627 USA
[2] Univ Rochester, Inst Opt, Rochester, NY 14620 USA
[3] Univ Rochester, Flaum Eye Inst, Rochester, NY 14642 USA
关键词
WAVE-FRONT SENSOR; SCANNING LASER OPHTHALMOSCOPY; RETINAL GANGLION-CELLS; WILD-TYPE MICE; IMAGE QUALITY; COHERENCE TOMOGRAPHY; CHROMATIC ABERRATION; OCULAR ABERRATIONS; ADAPTIVE OPTICS; VISUAL-ACUITY;
D O I
10.1364/BOE.2.000717
中图分类号
Q5 [生物化学];
学科分类号
070307 [化学生物学];
摘要
The Shack-Hartmann wavefront sensor (SHWS) spots upon which ocular aberration measurements depend have poor quality in mice due to light reflected from multiple retinal layers. We have designed and implemented a SHWS that can favor light from a specific retinal layer and measured monochromatic aberrations in 20 eyes from 10 anesthetized C57BL/6J mice. Using this instrument, we show that mice are myopic, not hyperopic as is frequently reported. We have also measured longitudinal chromatic aberration (LCA) of the mouse eye and found that it follows predictions of the water-filled schematic mouse eye. Results indicate that the optical quality of the mouse eye assessed by measurement of its aberrations is remarkably good, better for retinal imaging than the human eye. The dilated mouse eye has a much larger numerical aperture (NA) than that of the dilated human eye (0.5 NA vs. 0.2 NA), but it has a similar amount of root mean square (RMS) higher order aberrations compared to the dilated human eye. These measurements predict that adaptive optics based on this method of wavefront sensing will provide improvements in retinal image quality and potentially two times higher lateral resolution than that in the human eye. (C) 2011 Optical Society of America
引用
收藏
页码:717 / 738
页数:22
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