HIV-inhibitory prenylated xanthones and flavones from Maclura tinctoria

被引：148

作者：

Groweiss, A ^{[1
]}

Cardellina, JH ^{[1
]}

Boyd, MR ^{[1
]}

机构：

[1] NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Lab Drug Discovery Res & Dev,Dev Therapeut Progra, Frederick, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 11期

关键词：

D O I：

10.1021/np000175m

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The organic extract of the plant Maclura tinctoria exhibited moderate anti-HIV activity. Seven prenylated phenolic derivatives were isolated from the active fractions and characterized by spectroanalytical methods. New compounds macluraxanthone B (1), macluraxanthone C (2), and dihydrocudraflavone B (8) were identified.

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页码：1537 / 1539

页数：3

相关论文

共 19 条

[11] ON THE CONSTITUENTS OF THE MORACEAE PLANTS .7. COMPONENTS OF THE ROOT BARK OF CUDRANIA-TRICUSPIDATA .6. STRUCTURES OF 4 NEW ISOPRENYLATED XANTHONES, CUDRAXANTHONE-L, CUDRAXANTHONE-M, CUDRAXANTHONE-N, AND CUDRAXANTHONE-O FROM CUDRANIA-TRICUSPIDATA [J].

HANO, Y ;

MATSUMOTO, Y ;

SHINOHARA, K ;

SUN, JY ;

NOMURA, T .

PLANTA MEDICA, 1991, 57 (02) :172-175

[12]

HANO Y, 1990, HETEROCYCLES, V31, P1339

[13] HIV INHIBITORY NATURAL-PRODUCTS .7. THE CALANOLIDES, A NOVEL HIV-INHIBITORY CLASS OF COUMARIN DERIVATIVES FROM THE TROPICAL RAIN-FOREST TREE, CALOPHYLLUM-LANIGERUM [J].

KASHMAN, Y ;

GUSTAFSON, KR ;

FULLER, RW ;

CARDELLINA, JH ;

MCMAHON, JB ;

CURRENS, MJ ;

BUCKHEIT, RW ;

HUGHES, SH ;

CRAGG, GM ;

BOYD, MR .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (15) :2735-2743

[14] NOVEL ALKALOIDS FROM THE TROPICAL PLANT ANCISTROCLADUS-ABBREVIATUS INHIBIT CELL KILLING BY HIV-1 AND HIV-2 [J].

MANFREDI, KP ;

BLUNT, JW ;

CARDELLINA, JH ;

MCMAHON, JB ;

PANNELL, LL ;

CRAGG, GM ;

BOYD, MR .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (12) :3402-3405

[15] ISOPRENOID-SUBSTITUTED PHENOLIC-COMPOUNDS OF MORACEOUS PLANTS [J].

NOMURA, T ;

HANO, Y .

NATURAL PRODUCT REPORTS, 1994, 11 (02) :205-218

[16]

OKEEFE B, IN PRESS MOL PHARM

[17] NEW SOLUBLE-FORMAZAN ASSAY FOR HIV-1 CYTOPATHIC EFFECTS - APPLICATION TO HIGH-FLUX SCREENING OF SYNTHETIC AND NATURAL-PRODUCTS FOR AIDS-ANTIVIRAL ACTIVITY [J].

WEISLOW, OS ;

KISER, R ;

FINE, DL ;

BADER, J ;

SHOEMAKER, RH ;

BOYD, MR .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (08) :577-586

[18] OSAGE ORANGE PIGMENTS .14. STRUCTURE OF ALVAXANTHONE [J].

WOLFROM, ML ;

KOMITSKY, F ;

MUNDELL, PM .

JOURNAL OF ORGANIC CHEMISTRY, 1965, 30 (04) :1088-&

[19] OSAGE ORANGE PIGMENTS .13. ISOLATION OF 3 NEW PIGMENTS FROM ROOT BARK [J].

WOLFROM, ML ;

WINDRATH, OM ;

DICKEY, EE ;

KOMITSKY, F ;

LOOKER, JH ;

MCWAIN, P ;

THOMPSON, A .

JOURNAL OF ORGANIC CHEMISTRY, 1964, 29 (03) :689-&