Determination of nifedipine in human plasma by flow-injection tandem mass spectrometry

被引：24

作者：

Dankers, J

van den Elshout, J

Ahr, G

Brendel, E

van der Heiden, C

机构：

[1] BCO Analyt Serv, NL-4800 CD Breda, Netherlands

[2] Bayer, Inst Clin Pharmacol, Pharma Res Ctr, D-42096 Wuppertal, Germany

来源：

JOURNAL OF CHROMATOGRAPHY B | 1998年 / 710卷 / 1-2期

关键词：

nifedipine;

D O I：

10.1016/S0378-4347(98)00126-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

For use in clinical studies, a fast and sensitive assay method was developed for the determination of nifedipine in human plasma samples. The assay method is based on tandem mass spectrometry detection (HPLC-MS-MS). The effect of flow injection as well as HPLC separation on the results of the nifedipine determination were evaluated. The limit of quantification is 0.5 ng/ml and the accuracy (as determined by spiking recovery) was found to be good. (C) 1998 Elsevier Science BN. All rights reserved.

引用

收藏

页码：115 / 120

页数：6

相关论文

共 9 条

[1] PHOTOSTABILITY DETERMINATION OF COMMERCIALLY AVAILABLE NIFEDIPINE ORAL DOSAGE FORMULATIONS [J].

GRUNDY, JS ;

KHERANI, R ;

FOSTER, RT .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1994, 12 (12) :1529-1535

[2] DETERMINATION OF A NEW CALCIUM-ANTAGONIST AND ITS MAIN METABOLITE IN PLASMA BY THERMOSPRAY LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY [J].

HATADA, K ;

KIMURA, M ;

ONO, I ;

OZAKI, M .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1992, 583 (01) :116-121

[3] QUANTITATIVE-ANALYSIS OF THE DIHYDROPYRIDINES, 3-(2-FUROYL)-5-METHOXYCARBONYL-2,6-DIMETHYL-4-(2-NITROPHENYL)-1,4-DIHYDROPYRIDINE AND NIFEDIPINE, BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION [J].

HUEBERT, ND ;

SPEDDING, M ;

HAEGELE, KD .

JOURNAL OF CHROMATOGRAPHY, 1986, 353 :175-180

[4] PHOTODEGRADATION OF NIFEDIPINE RELATIVE TO NITRENDIPINE EVALUATED BY LIQUID AND GAS-CHROMATOGRAPHY [J].

LOGAN, BK ;

PATRICK, KS .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1990, 529 (01) :175-181

[5] DETERMINATION OF NIFEDIPINE IN HUMAN SERUM BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY - VALIDATION OF THE METHOD AND ITS USE IN BIOAVAILABILITY STUDIES [J].

MARTENS, J ;

BANDITT, P ;

MEYER, FP .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1994, 660 (02) :297-302

[6]

Mueck Wolfgang M., 1995, Journal of Chromatography A, V712, P45

[7] RAPID HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF NIFEDIPINE IN PLASMA WITH ONLINE PRECOLUMN SOLID-PHASE EXTRACTION [J].

NITSCHE, V ;

SCHUTZ, H ;

EICHINGER, A .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1987, 420 (01) :207-211

[8] GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC ANALYSIS OF PLASMA NIFEDIPINE [J].

PATRICK, KS ;

JARVI, EJ ;

STRAUGHN, AB ;

MEYER, MC .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1989, 495 :123-130

[9] DETERMINATION OF NIFEDIPINE AND ITS 3 PRINCIPAL METABOLITES IN PLASMA AND URINE BY AUTOMATED ELECTRON-CAPTURE CAPILLARY GAS-CHROMATOGRAPHY [J].

SCHMID, BJ ;

PERRY, HE ;

IDLE, JR .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1988, 425 (01) :107-119