Contrast-enhanced MRI of liver metastases: positive versus negative contrast agents

被引:3
作者
Hammerstingl, RM
Schwarz, W
Hochmuth, K
Staib-Sebler, E
Lorenz, M
Vogl, TJ
机构
[1] Goethe Univ Frankfurt, Inst Diagnost & Intervent Radiol, D-60590 Frankfurt, Germany
[2] Goethe Univ Frankfurt, Inst Allgemein & Viszeralchirurg, D-6000 Frankfurt, Germany
来源
RADIOLOGE | 2001年 / 41卷 / 01期
关键词
contrast agents; magnetic resonance (MR); liver metastases; gadolinium-chelates; iron oxides;
D O I
10.1007/s001170050924
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The development in oncologic liver surgery as well as modified interventional therapy strategies of the liver have resulted in improved diagnostic imaging. The evolution of contrast agents for MR imaging of the liver has proceeded along several different paths with the common goal of improving liver-lesion contrast. In MRI contrast agents act indirectly by their effects on relaxation times. Contrast agents used for hepatic MR imaging can be categorized in those that target the extracellular space, the hepatobiliary system, a nd the reticuloendothelial system. The first two result in a positive enhancement,the last one in a negative enhancement. Positive enhancers allow a better characterization of liver metastases using dynamic sequence protocols. Detection rate of liver metastases is increased using hepatobiliary contrast-enhanced MRI compared to unenhanced MRI. Negative enhancers, iron oxide particels, significantly increase tumor-to-liver contrast and allow detection of more lesions than other diagnostic methods. Iron-oxide enhanced MRI enables differential diagnosis of liver metastases comparing morphologic features using T2 and T1-weighted sequences.
引用
收藏
页码:24 / 39
页数:16
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