Sensitivity of different zygomycetes to the Penicillium chrysogenum antifungal protein (PAF)

被引：21

作者：

Galgoczy, L ^{[1
]}

Papp, T

Leiter, T

Marx, F

Pócsi, I

Vágvölgyi, C

机构：

[1] Univ Szeged, Dept Microbiol, Fac Sci, H-6701 Szeged, Hungary

[2] Univ Debrecen, Dept Microbiol & Biotechnol, H-4010 Debrecen, Hungary

[3] Innsbruck Med Univ, Dept Mol Biol, A-6020 Innsbruck, Austria

来源：

JOURNAL OF BASIC MICROBIOLOGY | 2005年 / 45卷 / 02期

关键词：

D O I：

10.1002/jobm.200410512

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The effects of the Penicillium chrysogenum low molecular mass antifungal protein (PAF) on selected fungal species belonging in the Zygomycetes were investigated. A total of 21 fungal isolates from 15 different genera (Absidia, Actinomucor, Cokeromyces, Gilbertella, Micromucor, Mortierella, Mucor, Mycotypha, Rhizomucor, Rhizopus, Saksenaea, Syncephalastrum, Thamnostylum, Umbelopsis and Zygorhynchus) were tested. The inhibitory potentials of PAF at 50 mu g ml(-1) on the germination of the sporangiospores and at 6.25-50 mu g ml(-1) on the hyphal extension were examined on different culture media. From among the fungi regarded as opportunistic human and/or animal pathogens, PAF exhibited inhibitory effects against Absidia, Mortierella, Rhizomucor and Rhizopus species.

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页码：136 / 141

页数：6

相关论文

共 13 条

[1] Diversity of antimicrobial peptides and their mechanisms of action [J].

Epand, RM ;

Vogel, HJ .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1999, 1462 (1-2) :11-28

[2] Antifungals: mechanism of action and resistance, established and novel drugs [J].

Georgopapadakou, NH .

CURRENT OPINION IN MICROBIOLOGY, 1998, 1 (05) :547-557

[3] Characterization of the Penicillium chrysogenum antifungal protein PAF [J].

Kaiserer, L ;

Oberparleiter, C ;

Weiler-Görz, R ;

Burgstaller, W ;

Leiter, E ;

Marx, F .

ARCHIVES OF MICROBIOLOGY, 2003, 180 (03) :204-210

[4] Small, basic antifungal proteins secreted from filamentous ascomycetes: a comparative study regarding expression, structure, function and potential application [J].

Marx, F .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2004, 65 (02) :133-142

[5] Cloning, structural organization and regulation of expression of the Penicillium chrysogenum paf gene encoding an abundantly secreted protein with antifungal activity [J].

Marx, F ;

Haas, H ;

Reindl, M ;

Stoffler, G ;

Lottspeich, F ;

Redl, B .

GENE, 1995, 167 (1-2) :167-171

[6] Emerging moulds:: Fusarium, Scedosporium and Zygomycetes in transplant recipients [J].

Nucci, M .

CURRENT OPINION IN INFECTIOUS DISEASES, 2003, 16 (06) :607-612

[7] Active internalization of the Penicillium chrysogenum antifungal protein PAF in sensitive aspergilli [J].

Oberparleiter, C ;

Kaiserer, L ;

Haas, H ;

Ladurner, P ;

Andratsch, M ;

Marx, F .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (11) :3598-3601

[8]

Peberdy John F., 1999, Acta Microbiologica et Immunologica Hungarica, V46, P165

[9] Mucormycosis and entomophthoramycosis: a review of the clinical manifestations, diagnosis and treatment [J].

Prabhu, RM ;

Patel, R .

CLINICAL MICROBIOLOGY AND INFECTION, 2004, 10 :31-47

[10] Zygomycetes in human disease [J].

Ribes, JA ;

Vanover-Sams, CL ;

Baker, DJ .

CLINICAL MICROBIOLOGY REVIEWS, 2000, 13 (02) :236-+