Synthesis and biological evaluation of C-13 amide-linked paclitaxel (Taxol) analogs

被引：33

作者：

Chen, SH ^{[1
]}

Farina, V ^{[1
]}

Vyas, DM ^{[1
]}

Doyle, TW ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,PRINCETON,NJ 08543

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 06期

关键词：

D O I：

10.1021/jo952067o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several C-13 amidopaclitaxel analogs have been synthesized during the course of our structure-activity relationship study at the C-13 position. These include 4-deacetyl-13-amidopaclitaxel (4), 13-amidopaclitaxel 4-(methyl carbonate) derivatives (5a,b), and 13-amidopaclitaxel (6). None of these novel C-13 amidopaclitaxel analogs retain any activity in the tubulin polymerization assay or the in vitro cytotoxicity assay.

引用

页码：2065 / 2070

页数：6

共 46 条

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