IL-17: overview and role in oral immunity and microbiome

被引：174

作者：

Abusleme, L. ^{[1
]}

Moutsopoulos, N. M. ^{[1
]}

机构：

[1] NIDCR, Oral Immun & Inflammat Unit, NIH, Bethesda, MD 20892 USA

来源：

ORAL DISEASES | 2017年 / 23卷 / 07期

关键词：

IL-17; oral mucosal immunity; Th17; oral microbiome; CHRONIC MUCOCUTANEOUS CANDIDIASIS; GROWTH-FACTOR-BETA; ROR-GAMMA-T; MEDIATED INTESTINAL INFLAMMATION; POLYENDOCRINE SYNDROME TYPE-1; T(H)17 CELL-DIFFERENTIATION; MUCOSAL HOST-DEFENSE; CXCL1; MESSENGER-RNA; CYTOKINE GM-CSF; NF-KAPPA-B;

D O I：

10.1111/odi.12598

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

Interleukin-17 (IL-17) is a multifaceted cytokine with diverse roles in both immune protection and also immunopathology. IL-17 has a well-recognized role in immune surveillance at mucosal and barrier surfaces, but also has been increasingly implicated as a driver of immunopathology in settings of autoimmunity and chronic inflammation. The current review introduces basic aspects of IL-17 biology and examines the protective and pathogenic roles of IL-17 with a focus on oral mucosal immunity and inflammation. Specific emphasis is given to the role of the IL-17 response as a catalyst in 'shaping the microbiome at the oral barrier'.

引用

页码：854 / 865

页数：12

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