Short report:: IgGI/IgG3 antibody responses to various analogs of recombinant yPfMSPl19 -: A study in immune adults living in areas of Plasmodium falciparum transmission

被引：15

作者：

Diallo, TO

Spiegel, A

Diouf, A

Perraut, R

Kaslow, DC

Garraud, O

机构：

[1] NIAID, Mol Vaccine Sect, NIH, Bethesda, MD 20892 USA

[2] Inst Pasteur, Epidemiol Unit, Dakar, Senegal

[3] Inst Pasteur, Unite Immunol, Dakar, Senegal

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2001年 / 64卷 / 3-4期

关键词：

D O I：

10.4269/ajtmh.2001.64.204

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

To further characterize protective-type (IgG1/IgG3) antibody responses to Plasmodium falciparum blood stage in putatively immune individuals' plasma, we have tested for various analogs of the 19 kDa C-terminus of the MSP1 antigen obtained as secreted recombinant proteins from Saccharomyces cerevisiae. One of four proteins was then identified on the basis of consistent IgG3, along with less variable IgG1 recognition. This protein has thus been selected for further functional assays of IgG1/IgG3 antibodies.

引用

页码：204 / 206

页数：3

共 14 条

[11] EXPRESSION AND ANTIGENICITY OF PLASMODIUM-FALCIPARUM MAJOR MEROZOITE SURFACE PROTEIN (MSP1(19)) VARIANTS SECRETED FROM SACCHAROMYCES-CEREVISIAE [J].