Biological targeting and innovative therapeutic interventions with phage-displayed peptides and structured nucleic acids (aptamers)

被引：15

作者：

Ahmadvand, Davoud ^{[1
]}

Rahbarizadeh, Fatemeh ^{[2
]}

Moghimi, Seyed Moein ^{[1
]}

机构：

[1] Univ Copenhagen, Ctr Pharmaceut Nanotechnol & Nanotoxicol, DK-2100 Copenhagen O, Denmark

[2] Tarbiat Modares Univ, Dept Med Biotechnol, Fac Med Sci, Tehran, Iran

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2011年 / 22卷 / 06期

关键词：

IN-VITRO SELECTION; CANCER-CELLS; TUMOR-GROWTH; DELIVERY; DNA; LIGANDS; SIRNAS; VIVO; OPTIMIZATION; DISCOVERY;

D O I：

10.1016/j.copbio.2011.02.012

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Diverse technologies such as phage display, cell systematic evolution of ligands by exponential enrichment and related modifications thereof are generating a wide range of peptide-based and structured nucleic acid (aptamers)-based ligands for therapeutic and diagnostic interventions in an unbiased biological context. Their impressive affinity and unprecedented target specificity make these ligands as ideal small-sized candidates for conjugation to macromolecules and nanoparticulate matters, thus opening the path to new and sophisticated design solutions for targeted therapy, disease detection and diagnosis. Vascular beds of many organs and tissue, cancer, immune and stem cells are among the key targets. These technologies are evaluated and selected recent examples of innovative biological targeting and therapeutic interventions with phage-displayed peptides and aptamers are discussed.

引用

页码：832 / 838

页数：7

共 57 条

[51] Liposome anchored vascular endothelial growth factor aptamers [J].

Willis, MC ;

Collins, B ;

Zhang, T ;

Green, LS ;

Sebesta, DP ;

Bell, C ;

Kellogg, E ;

Gill, SC ;

Magallanez, A ;

Knauer, S ;

Bendele, RA ;

Gill, PS ;

Janjic, N .

BIOCONJUGATE CHEMISTRY, 1998, 9 (05) :573-582

[52] DNA aptamer-micelle as an efficient detection/delivery vehicle toward cancer cells [J].

Wu, Yanrong ;

Sefah, Kwame ;

Liu, Haipeng ;

Wang, Ruowen ;

Tan, Weihong .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (01) :5-10

[53] Strategies for the discovery of therapeutic aptamers [J].

Yang, Xianbin ;

Li, Na ;

Gorenstein, David G. .

EXPERT OPINION ON DRUG DISCOVERY, 2011, 6 (01) :75-87

[54] Novel peptide ligands that bind specifically to mouse embryonic stem cells [J].

Zhao, Saijuan ;

Zhao, Wenxiu ;

Ma, Lan .

PEPTIDES, 2010, 31 (11) :2027-2034

[55] Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy [J].

Zhou, Jiehua ;

Li, Haitang ;

Li, Shirley ;

Zaia, John ;

Rossi, John J. .

MOLECULAR THERAPY, 2008, 16 (08) :1481-1489

[56] Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells [J].

Zhou, Jiehua ;

Swiderski, Piotr ;

Li, Haitang ;

Zhang, Jane ;

Neff, C. Preston ;

Akkina, Ramesh ;

Rossi, John J. .

NUCLEIC ACIDS RESEARCH, 2009, 37 (09) :3094-3109

[57] Internalizing Cancer Antibodies from Phage Libraries Selected on Tumor Cells and Yeast-Displayed Tumor Antigens [J].

Zhou, Yu ;

Zou, Hao ;

Zhang, Shaoyi ;

Marks, James D. .

JOURNAL OF MOLECULAR BIOLOGY, 2010, 404 (01) :88-99

← 1 2 3 4 5 6 →