Memantine decreases hippocampal glutamate levels: A magnetic resonance spectroscopy study

被引：23

作者：

Glodzik, Lidia ^{[1
]}

King, Kevin G. ^{[2
]}

Gonen, Oded ^{[2
]}

Liu, Songtao ^{[2
]}

De Santi, Susan ^{[1
]}

de Leon, Mony J. ^{[1
]}

机构：

[1] NYU, Sch Med, Ctr Brain Hlth, Dept Psychiat, New York, NY 10016 USA

[2] NYU, Ctr Brain Imaging, Dept Radiol, New York, NY 10016 USA

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2008年 / 32卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; excitotoxicity; glutamate; hippocampus; magnetic resonance spectroscopy; memantine;

D O I：

10.1016/j.pnpbp.2008.01.016

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Glutamate (Glu) is associated with excitotoxic cell damage. Memantine modulates the glutamate induced excitotoxicity in Alzheimer's disease (AD). No information is available as to the influence of memantine on in vivo brain glutamate levels. Hippocampal Glu levels were measured in cognitively impaired and normal individuals (n = 10) before and after 6 months of memantine treatment, using three dimensional high spatial resolution (0.5 cm(3) voxels) proton magnetic resonance spectroscopy at 3 T. These measurements were also repeated in a non-treated cognitively normal group (n = 6). Treatment with memantine decreased Glu/Cr (creatine) ratio in the left hippocampal region. Memantine reduced hippocampal glutamate levels, which may be consistent with its anti-excitotoxic property. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1005 / 1012

页数：8

共 42 条

[1]

Decreased glutamate plus glutamine in Alzheimer's disease detected in vivo with 1H-MRS at 0.5 T [J].

Antuono, PG ;

Jones, JL ;

Wang, Y ;

Li, SJ .

NEUROLOGY, 2001, 56 (06) :737-742

[2]

Bakchine S, 2007, J ALZHEIMERS DIS, V11, P471

[3]

Effect of windowing and zero-filled reconstruction of MRI data on spatial resolution and acquisition strategy [J].

Bernstein, MA ;

Fain, SB ;

Riederer, SJ .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2001, 14 (03) :270-280

[4]

Regional N-acetylaspartate reduction in the hippocampus detected with fast proton magnetic resonance spectroscopic imaging in patients with Alzheimer disease [J].

Block, W ;

Jessen, F ;

Träber, F ;

Flacke, S ;

Manka, C ;

Lamerichs, R ;

Keller, E ;

Heun, R ;

Schild, H .

ARCHIVES OF NEUROLOGY, 2002, 59 (05) :828-834

[5]

SPATIAL LOCALIZATION IN NMR-SPECTROSCOPY INVIVO [J].

BOTTOMLEY, PA .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 508 :333-348

[6]

SELECTIVE FOURIER-TRANSFORM LOCALIZATION [J].

BROOKER, HR ;

MARECI, TH ;

MAO, JT .

MAGNETIC RESONANCE IN MEDICINE, 1987, 5 (05) :417-433

[7]

Magnetic resonance spectroscopy in Alzheimer's disease:: focus on N-acetylaspartate [J].

Chen, JG ;

Charles, HC ;

Barboriak, DP ;

Doraiswamy, PM .

ACTA NEUROLOGICA SCANDINAVICA, 2000, 102 :20-26

[8]

Amino acids and transaminases activity in ventricular CSF and in brain of normal and Alzheimer patients [J].

D'Aniello, A ;

Fisher, G ;

Migliaccio, N ;

Cammisa, G ;

D'Aniello, E ;

Spinelli, P .

NEUROSCIENCE LETTERS, 2005, 388 (01) :49-53

[9]

Danysz W, 1998, PHARMACOL REV, V50, P597

[10]

REGULATION OF PHOSPHATE-ACTIVATED GLUTAMINASE (PAG) BY GLUTAMATE ANALOGS [J].

DAWSON, R ;

WALLACE, DR .

NEUROCHEMICAL RESEARCH, 1993, 18 (02) :125-132

← 1 2 3 4 5 →