Cardenolides from Antiaris toxicaria as potent selective Nur77 modulators

被引：39

作者：

Jiang, Miao-Miao ^{[1
]}

Dai, Yi ^{[2
,3
]}

Gao, Hao ^{[2
,3
]}

Zhang, Xue ^{[1
]}

Wang, Guang-Hui ^{[4
]}

He, Jia-You ^{[4
]}

Hu, Qiong-Ying ^{[5
]}

Zeng, Jin-Zhang ^{[4
]}

Zhang, Xiao-Kun ^{[5
]}

Yao, Xin-Sheng ^{[1
,2
,3
]}

机构：

[1] Shenyang Pharmaceut Univ, Coll Tradit Chine Med, Shenyang 110016, Peoples R China

[2] Jinan Univ, Inst Tradit Chinese Med, Guangzhou 510632, Guangdong, Peoples R China

[3] Jinan Univ, Inst Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[4] Xiamen Univ, Inst Biomed Res, Xiamen 361005, Peoples R China

[5] Burnham Inst Med Res, La Jolla, CA 92037 USA

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 07期

关键词：

Antiaris toxicaria; cardenolides; Nur77; anticancer;

D O I：

10.1248/cpb.56.1005

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Toxicarioside D (1), a new cardenolide, along with 10 other known ones, was isolated from the stem of Antiaris toxicaria LESCH. by bioassay-guided fractionation. Their structures were determined on the basis of spectroscopic analysis. All the reported compounds effectively inhibited the growth of various cancer cell lines at nanomolar concentrations. Inhibition of cancer cell growth was accompanied with induction of the expression of Nur77, a potent apoptotic member of the steroid/thyroid hormone receptor superfamily.

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页码：1005 / 1008

页数：4

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