Toxicarioside A. A new cardenolide isolated from Antiaris toxicaria latex-derived dart poison. Assignment of the H-1- and C-13-NMR shifts for an antiarigenin aglycone.

被引：19

作者：

Carter, CA

Forney, RW

Gray, EA

Gehring, AM

Schneider, TL

Young, DB

Lovett, CM

Scott, L

Messer, AC

Richardson, DP

机构：

[1] WILLIAMS COLL, DEPT CHEM, WILLIAMSTOWN, MA 01267 USA

[2] BOSTON UNIV, DEPT CHEM, BOSTON, MA 02215 USA

[3] USAID, DEPT STATE, WASHINGTON, DC 20521 USA

来源：

TETRAHEDRON | 1997年 / 53卷 / 40期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4020(97)00895-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioassay-guided fractionation of the chloroform/methanol extract of a dart poison from Indonesian Borneo (Kalimantan), derived from Antiaris toxicaria latex, has led to the isolation of a new cardenolide, toxicarioside A [1]. The structure of 1 was deduced by analysis of spectroscopic data and has led to the first assignment of the H-1- and C-13-NMR shifts for an antiarigenin aglycone. The bioassay employed to isolate cardenolide 1 involves inhibition of Na+/K+-ATPase and mimics the suspected mode of action of these ''cardiac-glycoside'' toxins. (C) 1997 Elsevier Science Ltd.

引用

页码：13557 / 13566

页数：10

共 43 条

[1] THE CONFORMATIONAL BEHAVIOR OF THE CARDIAC GLYCOSIDE DIGOXIN AS INDICATED BY NMR-SPECTROSCOPY AND MOLECULAR-DYNAMICS CALCULATIONS [J].