Life History, Immune Function, and Intestinal Helminths: Trade-Offs Among Immunoglobulin E, C-Reactive Protein, and Growth in an Amazonian Population

被引:84
作者
Blackwell, Aaron D. [1 ,2 ,3 ]
Snodgrass, J. Josh [2 ,3 ]
Madimenos, Felicia C. [2 ,3 ]
Sugiyama, Lawrence S. [1 ,2 ,3 ]
机构
[1] Univ Calif Santa Barbara, Ctr Evolutionary Psychol, Santa Barbara, CA 93106 USA
[2] Univ Oregon, Dept Anthropol, Eugene, OR 97403 USA
[3] Univ Oregon, Inst Cognit & Decis Sci, Eugene, OR 97403 USA
关键词
TOTAL SERUM IGE; ASCARIS-LUMBRICOIDES; HYPERIMMUNOGLOBULINEMIA-E; INFECTION INTENSITY; ENZYME-IMMUNOASSAY; INDIGENOUS PEOPLES; EARLY ORIGINS; WEIGHT-GAIN; CHILDREN; INFLAMMATION;
D O I
10.1002/ajhb.21092
中图分类号
Q98 [人类学];
学科分类号
030303 ;
摘要
Objectives. Infection with helminths is associated with shifts in host immunity, including increased production of immunoglobulin E (IgE) and reduced inflammation. Given limited energy budgets, these shifts may involve changes in energy allocation toward competing demands. Here we test for potential trade-offs between growth, IgE, and the inflammatory marker C-reactive protein (CRP). Methods. Dried blood spots and anthropometrics were collected from 162 Shuar forager-horticulturalists from a village in southeastern Ecuador. Enzyme-linked immunosorbent assays (ELISAs) were used to measure IgE and CRP. Relationships among IgE, CRP, and anthropometrics were examined in three groups: children aged 2-7 years (n = 63), children aged 8-15 (n = 61), and adults over age 18 (n = 37). Results. Geometric mean IgE was 1,196 IU ml(-1) while geometric mean CRP was 1.33 mg l(-1). In children, IgE and CRP were negatively correlated (r = -0.21, P = 0.02, df = 122). Controlling for fat stores and age, IgE was associated with lower stature in children (t = -2.04, P = 0.04, df = 109), and adults (t = -3.29, P < 0.01, df = 33). In children there was a significant interaction between age and CRP, such that in younger children CRP was associated with shorter stature, but in older children was associated with greater stature (t = 2.15, P = 0.04, df = 109). Conclusions. These results suggest that infection with helminths may have hidden costs associated with immunological changes, and that these costs may ultimately affect growth and other life history parameters. Am. J. Hum. Biol. 22:836-848, 2010. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码:836 / 848
页数:13
相关论文
共 97 条
[21]   Age- and infection intensity-dependent cytokine and antibody production in human trichuriasis: The importance of IgE [J].
Faulkner, H ;
Turner, J ;
Kamgno, J ;
Pion, SD ;
Boussinesq, M ;
Bradley, JE .
JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (05) :665-672
[22]   Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy [J].
Fox, JG ;
Beck, P ;
Dangler, CA ;
Whary, MT ;
Wang, TC ;
Shi, HN ;
Nagler-Anderson, C .
NATURE MEDICINE, 2000, 6 (05) :536-542
[23]  
GADGIL M, 1970, American Naturalist, V104, P1, DOI 10.1086/282637
[24]   Adult socioeconomic position, C-reactive protein and interleukin-6 in the Whitehall II prospective study [J].
Gimeno, David ;
Brunner, Eric J. ;
Lowe, Gordon D. O. ;
Rumley, Ann ;
Marmot, Michael G. ;
Ferrie, Jane E. .
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2007, 22 (10) :675-683
[25]   Early life events and their consequences for later disease: A life history and evolutionary perspective [J].
Gluckman, Peter D. ;
Hanson, Mark A. ;
Beedle, Alan S. .
AMERICAN JOURNAL OF HUMAN BIOLOGY, 2007, 19 (01) :1-19
[26]  
GODFREY R C, 1975, Clinical Allergy, V5, P201, DOI 10.1111/j.1365-2222.1975.tb01853.x
[27]   The effect of market economies on the well-being of indigenous peoples and on their use of renewable natural resources [J].
Godoy, R ;
Reyes-García, V ;
Byron, E ;
Leonard, WR ;
Vadez, V .
ANNUAL REVIEW OF ANTHROPOLOGY, 2005, 34 :121-138
[28]   High heritability but uncertain mode of inheritance for total serum IgE level and schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population [J].
Grant, Audrey V. ;
Araujo, Maria Ilma ;
Ponte, Eduardo Vieira ;
Oliveira, Ricardo Riccio ;
Cruz, Alvaro A. ;
Barnes, Kathleen C. ;
Beaty, Terri H. .
JOURNAL OF INFECTIOUS DISEASES, 2008, 198 (08) :1227-1236
[29]   HUMAN IGE, IGG4 AND RESISTANCE TO REINFECTION WITH SCHISTOSOMA-HAEMATOBIUM [J].
HAGAN, P ;
BLUMENTHAL, UJ ;
DUNN, D ;
SIMPSON, AJG ;
WILKINS, HA .
NATURE, 1991, 349 (6306) :243-245
[30]  
HAGEL I, 1993, CLIN EXP IMMUNOL, V94, P80, DOI 10.1111/j.1365-2249.1993.tb05981.x