A comparative study of the potential of acrylic and sol-gel polymers for molecular imprinting

被引:61
作者
Cummins, W [1 ]
Duggan, P [1 ]
McLoughlin, P [1 ]
机构
[1] Waterford Inst Technol, Seperat Sci Res Grp, Waterford, Ireland
关键词
molecular imprinting; molecular recognition; 2-aminopyridine; sol-gel; acrylic;
D O I
10.1016/j.aca.2005.01.042
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The successful molecular imprinting of 2-aminopyridine (2-apy) in bulk polymerisations of acrylic and sol-gel based polymers has been achieved. Both polymeric systems reveal varying degrees of affinity in rebinding the original template as well as a number of structural analogues. Rebinding was conducted in chloroform, acetonitrile and methanol in order to assess the role of hydrogen bonding in imprinting. The acrylic imprinted polymer retained approximately 50% of the template in rebinding studies in chloroform compared to 100% for the sol-gel. However, this higher affinity for the sol-gel was accompanied by a higher degree of non-specific binding. While the acrylic polymer performed poorly in acetonitrile, the sol-gel maintained a high degree of discrimination. The acrylic polymer exhibited little discrimination between imprinted and reference polymers for 3-aminopyridine (3-apy) indicating the high selectivity of the MIP polymer for 2-apy relative to 3-apy. This selectivity was reduced in acetonitrile. Selectivity of the sol-gel for 2-apy in chloroform was poor as 3-apy was retained to a similar degree. Comparable results were obtained in acetonitrile. 4-Aminopyridine (4-apy) bound strongly to all polymers in all solvents and proved very difficult to remove due to the high degree of non-specific binding for both polymeric matrices. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:52 / 60
页数:9
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