Apolipoprotein E genotyping in a sample of Colombian patients with Alzheimer's disease

被引：31

作者：

Arboleda, GH

Yunis, JJ

Pardo, R

Gómez, CM

Hedmont, D

Arango, G

Arboleda, H

机构：

[1] Univ Nacl Colombia, Fac Med, Genet Inst, Bogota, Colombia

[2] Univ Nacl Colombia, Fac Med, Dept Pathol, Bogota, Colombia

[3] Univ Nacl Colombia, Fac Med, Dept Neurol, Bogota, Colombia

[4] Univ Nacl Colombia, Fac Med, Dept Pediat, Bogota, Colombia

来源：

NEUROSCIENCE LETTERS | 2001年 / 305卷 / 02期

关键词：

Alzheimer disease; apolipoprotein E; case-control study; Hispano-Americans; Caucasians-Mestizo; Colombia;

D O I：

10.1016/S0304-3940(01)01829-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apolipoprotein E e4 (APOEe4) allele has been associated with an increased risk for Alzheimer's disease (AD) in diverse populations. Few studies have been carried out in Hispano-Americans and results are inconclusive due to ethnic diversity. This study determined the frequency of APOE alleles in a group of 61 Caucasian-Mestizos patients with probable AD, and 61 age- and sex-matched controls. APOEe4 frequency was 36.8% for patients, and 8.2% for controls (P < 0.0001; OR 7.6). Genotype frequencies differ between the two groups (P < 0.0001). Genotype 3/3 was the most common. Frequency of genotypes 3/4, 4/4 and 2/4 were higher in patients than in the controls. Our results show a highly significant association of APOEe4 with AD, and implies the importance of APOEe4 as a risk factor in this population. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：135 / 138

页数：4

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