Model studies towards stephaoxocanes: Construction of the 2-oxa-4-aza-phenalene core of stephaoxocanidine and eletefine

被引：21

作者：

Bianchi, DA

Cipulli, MA

Kaufman, TS

机构：

[1] Consejo Nacl Invest Cient & Tecn, UNR, Inst Quim Organ Sintesis, Rosario, Santa Fe, Argentina

[2] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, RA-2000 Rosario, Santa Fe, Argentina

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 24期

关键词：

electrophilic substitution; cyclization; nitrogen heterocycles; natural products;

D O I：

10.1002/ejoc.200300548

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The construction of the polysubstituted 1H,3H-2-oxa-4-aza-phenalene 4 by means of consecutive oxa-Pictet-Spengler and Jackson cyclizations is reported. This compound contains the ABC ring system of the novel isoquinoline alkaloids stephaoxocanidine and eletefine, found in Stephania cephorantha and Cissampelos glaberrima. Both these species are Menispermaceae used in folk medicine in the Far East and Brazil. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

引用

页码：4731 / 4736

页数：6

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