The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor

被引：38

作者：

Abbracchio, MP

Burnstock, G

Boeynaems, JM

Barnard, EA

Boyer, JL

Kennedy, C

Miras-Portugal, MT

King, BF

Gachet, C

Jacobson, KA

Weisman, GA

机构：

[1] Royal Free & Unvi Coll Med Sch Sch, Auton Neurosci Inst, London NW3 2PF, England

[2] Univ Milan, Dept Pharmacol Sci, I-20133 Milan, Italy

[3] Free Univ Brussels, IRIBHM, B-1070 Brussels, Belgium

[4] Free Univ Brussels, Erasme Hosp, Dept Med Chem, B-1070 Brussels, Belgium

[5] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1PD, England

[6] Inspire Pharmaceut Inc, Mol Pharmacol, Durham, NC 27703 USA

[7] Univ Strathclyde, Dept Physiol & Pharmacol, Glasgow G4 0NR, Lanark, Scotland

[8] Univ Complutense Madrid, Dept Bioquim, E-28040 Madrid, Spain

[9] EFS Alsace, INSERM, U311, F-67065 Strasbourg, France

[10] NIDDK, Bioorgan Chem Lab, Bethesda, MD 20892 USA

[11] Univ Missouri, Dept Biochem, Columbia, MO 65212 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 01期

关键词：

D O I：

10.1016/j.tips.2004.10.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The P2Y receptor family currently encompasses eight members (P2Y(1,2,4,6,11,12,13,14) receptors) that are activated by extracellular adenine and/or uracil nucleotides, or, in the case of the P2Y(14) receptor, by sugar-nucleotides, and are each characterized by the typical seven-transmembrane domain topology of G-protein-coupled receptors (GPCRs) [1]. For several years, it has been known that a series of 'orphan' GPCRs (i.e. cloned receptors available in the public database for which a natural ligand has not yet been identified) share significant sequence identity with the eight genuine P2Y receptors [1,2] and thus putatively represent novel members of the P2Y receptor family.

引用

页码：8 / 9

页数：2

共 8 条

[1] Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family [J].