Protective effect of the HLA-Bw4I80 epitope and the killer cell immunoglobulin-like receptor 3DS1 gene against the development of hepatocellular carcinoma in patients with hepatitis C virus infection

被引：104

作者：

López-Vázquez, A

Rodrigo, L

Martinez-Borra, J

Pérez, R

Rodríguez, M

Fdez-Morera, JL

Fuentes, D

Rodriguez-Rodero, S

González, S

López-Larrea, C

机构：

[1] Hosp Univ Cent Asturias, Dept Immunol, Oviedo 33006, Spain

[2] Hosp Univ Cent Asturias, Dept Gastroenterol, Oviedo 33006, Spain

[3] Univ Oviedo, Dept Funct Biol, Oviedo, Spain

来源：

JOURNAL OF INFECTIOUS DISEASES | 2005年 / 192卷 / 01期

关键词：

D O I：

10.1086/430351

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of the present study was to investigate, in 152 Spanish patients infected with hepatitis C virus (HCV), the possibility that killer cell immunoglobulin-like receptors (KIRs) influence progression to hepatocellular carcinoma. KIRs are related to the activation and inhibition of natural killer cells and may play an important role in the innate response against infection with such viruses as HCV. We found that the human leukocyte antigen-Bw4I80 epitope and the KIR3DS1 gene were more frequent in HCV carriers than in patients with hepatocellular carcinoma. Moreover, these associations were not independent of each other-the KIR3DS1/Bw4I80 genotype clearly was also more frequent in HCV carriers.

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页码：162 / 165

页数：4

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